钙离子霉素

钙离子霉素

货号:
II0820

品牌:
Jinpan

钙离子霉素

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产品简介
含量 Purity≥98%
EC EINECS 617-954-4
别名 罗红霉素钙盐
CAS 56092-82-1
分子式 C41H70O9Ca
分子量 747.1
纯度 ≥98%
单位
SMILES O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2]
靶点 Calcium Channel
规格 1mg

是一种有效的,选择性的钙离子载体 (calcium ionophore),也是一种抗生素。能够促进细胞凋亡,诱导蛋白激酶C (PKC) 激活。

使用本产品的应用案例(仅供参考

In Vitro

Cell(the peripheral blood lymphocytes, 1 μg/ml ionomycin calcium salt, 5h)

Blood from the M6-immunized (three doses) mice or rhesus monkeys was collected at and 28 days post-infection. Red blood cells were removed, and the peripheral blood lymphocytes were washed and suspended in RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum, 100 U/mL penicillin and 100 μg/mL streptomycin. Then, the cells were cultured for 5 h in the presence of phorbol 12-myristate 13-acetate (PMA) (50 ng/ml;Jinpan),ionomycin calcium salt (1 μg/ml; Jinpan) and GolgiStop (0.67 μl/ml)

来源文献:Xu X, Feng X, Wang L, Yi T, Zheng L, Jiang G, Fan S, Liao Y, Feng M, Zhang Y, Li D, Li Q. A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect. PLoS Pathog. 2020 Aug 10;16(8):e1008703. doi: 10.1371/journal.ppat.1008703. PMID: 32776994; PMCID: PMC7440667.