钙离子霉素
含量 | Purity≥98% |
EC | EINECS 617-954-4 |
别名 | 罗红霉素钙盐 |
CAS | 56092-82-1 |
分子式 | C41H70O9Ca |
分子量 | 747.1 |
纯度 | ≥98% |
单位 | 支 |
SMILES | O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2] |
靶点 | Calcium Channel |
规格 | 1mg |
是一种有效的,选择性的钙离子载体 (calcium ionophore),也是一种抗生素。能够促进细胞凋亡,诱导蛋白激酶C (PKC) 激活。
使用本产品的应用案例(仅供参考)
In Vitro
Cell(the peripheral blood lymphocytes, 1 μg/ml ionomycin calcium salt, 5h)
Blood from the M6-immunized (three doses) mice or rhesus monkeys was collected at and 28 days post-infection. Red blood cells were removed, and the peripheral blood lymphocytes were washed and suspended in RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum, 100 U/mL penicillin and 100 μg/mL streptomycin. Then, the cells were cultured for 5 h in the presence of phorbol 12-myristate 13-acetate (PMA) (50 ng/ml;Jinpan),ionomycin calcium salt (1 μg/ml; Jinpan) and GolgiStop (0.67 μl/ml)
来源文献:Xu X, Feng X, Wang L, Yi T, Zheng L, Jiang G, Fan S, Liao Y, Feng M, Zhang Y, Li D, Li Q. A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect. PLoS Pathog. 2020 Aug 10;16(8):e1008703. doi: 10.1371/journal.ppat.1008703. PMID: 32776994; PMCID: PMC7440667.