钙离子霉素
| 含量 | Purity≥98% |
| EC | EINECS 617-954-4 |
| 别名 | 罗红霉素钙盐 |
| CAS | 56092-82-1 |
| 分子式 | C41H70O9Ca |
| 分子量 | 747.1 |
| 纯度 | ≥98% |
| 单位 | 支 |
| SMILES | O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2] |
| 靶点 | Calcium Channel |
| 规格 | 1mg |
是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种抗生素。能够促进细胞凋亡，诱导蛋白激酶C (PKC) 激活。
使用本产品的应用案例（仅供参考）
In Vitro
Cell（the peripheral blood lymphocytes, 1 μg/ml ionomycin calcium salt, 5h）
Blood from the M6-immunized (three doses) mice or rhesus monkeys was collected at and 28 days post-infection. Red blood cells were removed, and the peripheral blood lymphocytes were washed and suspended in RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum, 100 U/mL penicillin and 100 μg/mL streptomycin. Then, the cells were cultured for 5 h in the presence of phorbol 12-myristate 13-acetate (PMA) (50 ng/ml;Jinpan),ionomycin calcium salt (1 μg/ml; Jinpan) and GolgiStop (0.67 μl/ml)
来源文献：Xu X, Feng X, Wang L, Yi T, Zheng L, Jiang G, Fan S, Liao Y, Feng M, Zhang Y, Li D, Li Q. A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect. PLoS Pathog. 2020 Aug 10;16(8):e1008703. doi: 10.1371/journal.ppat.1008703. PMID: 32776994; PMCID: PMC7440667.