1-Deoxynojirimycin；脱氧野尻霉素
货号：
ID0910
品牌：
Jinpan
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产品简介
| MDL | MFCD00063474 |
| EC | EINECS 606-239-2 |
| InChIKey | LXBIFEVIBLOUGU-JGWLITMVSA-N |
| InChI | InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 |
| PubChem CID | 29435 |
| 别名 | 1-脱氧氮杂-D-葡萄糖;1-去氧野艽霉素;(+)-1-deoxynojirimycin |
| 英文名称 | 1-Deoxynojirimycin |
| CAS | 19130-96-2 |
| 分子式 | C6H13NO4 |
| 分子量 | 163.17 |
| 纯度 | HPLC≥98% |
| 单位 | 支 |
| 生物活性 | 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. |
| In Vitro | 1-Deoxynojirimycin (DNJ) up to 200 μmol/L does not influence survival of HUVECs. DNJ behaves as an antioxidant, decreases ROS production, and delays cellular senescence[4]. |
| In Vivo | 1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect .1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3]. |
| SMILES | O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O |
| 靶点 | α-glucosidase |
| 动物实验 | Cytotoxicity of DNJ is assessed using a WST-8 assay. HUVECs at 80% confluency are trypsinized and transferred to 96-well plates (4000 cells/well). Stock solutions of DNJ are prepared in HuMedia-EG2 medium. DNJ test media are prepared from the stock solutions and diluted to final concentrations of 0-200 μmol/L in HuMedia-EG2 medium. After incubation for 24 h at 37℃, the cells are placed in 200 μL of fresh HuMedia-EG2 medium with various concentrations of DNJ. After 24 or 48 h, 10 μL WST-8 solution is added to each well. After incubation for 3 h at 37℃, cytotoxicity is measured using a microplate reader at a wavelength of 450 nm and a reference wavelength of 655 nm.[4] |
| 数据来源文献 | [1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT – Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232 [3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14. [4]. E S, Kijima R, Honma T, Yamamoto K, Hatakeyama Y, Kitano Y, Kimura T, Nakagawa K, Miyazawa T, Tsuduki T. 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. Exp Gerontol. 2014 Jul;55:63-9. |
| 规格 | 5mg 10mg |
是一种有效的α葡萄糖苷酶抑制剂。