AP26113-analogCAS号： 1197958-12-5分子式： C26H34ClN6O2P分子量： 529.01描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AP26113-analog (ALK-IN-1) is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
布格替尼类似物;ALK-IN-1；AP26113
|
| 外观 |
Light yellow powder
|
| 可溶性/溶解性 |
Ethanol ：98 mg/mL (185.3 mM)
DMSO ：42 mg/mL (79.4 mM) |
| 生物活性 | |
| 靶点 |
ALK
|
| In vitro(体外研究) |
Brigatinib and AP26113-analog have similar potency against the triple-mutant EGFR with IC50 values of <100 nM. AP26113-analog suppresses phosphorylation of EGFR and its downstream signalling pathway in cells expressing all types of EGFR mutations.
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分子结构图
