ARC 239 dihydrochloride hydrateCAS号： 67339-62-2分子式： C24H29N3O3•2HCl•xH2O分子量： 480.43描述应用纯度储存/保存方法形态外观折射率Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
ARC 239 dihydrochloride hydrate is a selective α2B-AR adrenoceptor antagonist with a pKD value of 8.8. This antagonist is known to display inhibitory effects on α2A-AR (α2A) and α2D receptors with pKD values of 6.7 and 6.4 respectively. Studies indicate that ARC 239 dihydrochloride is 100-fold more selective towards the α2B-AR (α2B adrenoceptor) than chlorpromazine and 7-hydroxychlorpromazine. Studies conducted on pentobarbital-treated dogs and rats show that ARC 239 dihydrochloride competitively antagonizes pressor responses to adrenaline, while inhibiting these pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium. ARC 239 dihydrochloride hydrate is an inhibitor of α2B-AR.
|
| 应用 |
A selective α2B-AR adrenoreceptor antagonist
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at 4° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 外观 |
Powder
|
| 折射率 |
n20D 1.58 (Predicted)
|
| Ki 数据 |
α1A-AR: Ki= 1 nM (human); α2C-AR: Ki= 10 nM (human); α2B-AR: Ki= 10 nM (human)
|
| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and water (100 mM).
|
| MDL |
MFCD16875414
|
| PubChem CID |
10345075
|