Morin hydrate；桑色素
| MDL | MFCD00006826 |
| EC | EINECS 207-542-9 |
| 别名 | 桑黄素;AluminumIonophoreI |
| 英文名称 | Morin hydrate |
| CAS | 480-16-0 |
| 分子式 | C15H10O7 |
| 分子量 | 302.24 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| SMILES | O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=CC(O)=CC(O)=C13 |
| 靶点 | Others |
| 规格 | 5mg 10mg 20mg |
Amfenac Sodium Hydrate；氨芬酸钠水合物
| MDL | MFCD00941383 |
| EC | EINECS 1592732-453-0 |
| 别名 | 去甲文拉法辛;Amfenacsodiummonohydrate |
| 英文名称 | Amfenac Sodium Hydrate |
| CAS | 61618-27-7 |
| 分子式 | C15H12NO3·H2O·Na |
| 分子量 | 295.27 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Amfenac Sodium Hydrate 是一个 COX-2 抑制剂。[1-2] |
| In Vitro | 转染以表达COX-2的细胞具有比不那些细胞更高的增殖率。添加Amfenac钠水合物显着降低了所有细胞系的增殖速率。通过添加黑素瘤条件培养基抑制巨噬细胞产生的一氧化氮, 添加Amfenac钠水合物部分克服了这种抑制作用[1]。结果表明, Amfenac Sodium Hydrate抑制B-葡萄糖醛酸酶的释放：5×10-4M Amfenac钠水合物分别在10-8和10-7M FMLP存在下抑制酶的释放35.3和16.3％。在10-8M FMLP孵育16分钟期间, 添加10-4M Amfenac钠水合物导致28.3％的聚集性多形核白细胞 (PMNs) 聚集[2]。 |
| SMILES | O=C([O-])CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N.[H]O[H].[Na+] |
| 靶点 | COX |
| 细胞实验 | 转染人葡萄膜黑色素瘤细胞系以组成型表达COX-2, 并测量使用两种不同方法的这些细胞的增殖速率, 添加和不添加Amfenac钠水合物。在暴露于来自两组细胞的黑素瘤条件培养基以及含有和不含有Amfenac钠的水合物后, 测量巨噬细胞产生的一氧化氮[1]。 |
| 数据来源文献 | [1]. Marshall JC, et al. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog. 2007 Nov 27; 6:17.
[2]. Matsumoto T, et al. Effect of a non-steroidal anti-inflammatory drug (amfenac sodium) on polymorphonuclear leukocytes. Pharmacol Res Commun. 1982 Jun; 14 (6) :523-32. |
| 备注 | 以上数据均来自公开文献, Jinpan暂未进行独立验证, 仅供参考。 These protocols are for reference only. Jinpan does not independently validate these methods. |
| 规格 | 10mg 50mg 100mg |
Levofloxacin (hydrate) 左氧氟沙星
| EC | EINECS 604-067-2 |
| MDL | MFCD07772024 |
| 别名 | 乳酸左氧氟沙星 |
| CAS | 138199-71-0 |
| 分子式 | C18H20FN3O4·1/2H2O |
| 分子量 | 370.38 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| SMILES | O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O.[0.5H2O] |
| 靶点 | Bacterial;Topoisomerase |
| 规格 | 50mg 10mM*1mL in DMSO 100mg |
是抗生素化合物，抑制细菌DNA旋转酶活性。
Terpin Hydrate
| CAS | 06-01-2451 |
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 750mg |
Alendronate sodium hydrateCAS号： 121268-17-5分子式： C4H13NO7P2.3H2O.Na分子量： 325.13描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Alendronate (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts. It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). It efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 – 70 uM). And it also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells). |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
阿仑膦酸钠；Alendronate；MK 217；G-704650 Adronat
|
| 外观 |
white solid
|
| 可溶性/溶解性 |
DMSO ：20 mg/mL (61.3 mM) with gentle warming
Water ：20 mg/mL (61.3 mM) with gentle warming |
| 生物活性 | |
| In vitro(体外研究) |
Alendronate, acting directly on osteoclasts, inhibits a rate-limiting step in the cholesterol biosynthesis pathway, essential for osteoclast function. Alendronate inhibits the isoprenoid biosynthesis pathway and interferes with protein prenylation, as a result of reduced geranylgeranyl diphosphate levels. Alendronate inhibits the incorporation of mevalonolactone into proteins of 18-25 kDa and into nonsaponifiable lipids, including sterols in osteoclasts. Alendronate causes a dose-dependent inhibition of MVA incorporation into sterols and a concomitant increase in incorporation of radiolabel into IPP and DMAPP.
|
| In vivo(体内研究) |
Alendronate causes erosions in the rabbit stomach, but not antral ulceration in rats. Alendronate increases the incidence and size of indomethacin-induced antral ulcers. Alendronate also enhances indomethacin-induced gastricdamage in the rat, and delayed gastric ulcer healing. Alendronate (0.04-0.1 mg/kg twice weekly or 0.1 mg/kg weekly) partially blocks the establishment of bone metastases by human PC-3 ML cells and results in tumor formation in the peritoneum and other soft tissues. Alendronate pretreatment of mice (0.1 mg/kg twice weekly or weekly) and dosing along with taxol (10-50 mg/kg/day, twice weekly, or weekly) blocks the growth of PC-3 ML tumors in the bone marrow and soft tissues in a statistically significant manner and improves survival rates significantly by 4-5 weeks.
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分子结构图
AH 23848, calcium salt hydrate分子式： [C29H34NO5]2•Ca2+分子量： 993.25描述应用储存/保存方法形态IC50可溶性/溶解性
| 产品描述 | |
| 描述 |
Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH-23848 is a dual antagonist of TP1 and EP4 receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 μM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH-23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4. Through inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, as well as the proliferation of fibroblasts, as well as reduces metastasis in a murine model of metastatic breast cancer.
|
| 应用 |
An activator of T prostanoid receptor
|
| 储存/保存方法 |
Store at -20° C
|
| 形态 |
Solid
|
| 基本信息 | |
| IC50 |
TXA2-induced platelet aggregation: IC50 = 0.26 µM
|
| 可溶性/溶解性 |
Soluble in DMSO (~5 mg/ml).
|
ARC 239 dihydrochloride hydrateCAS号： 67339-62-2分子式： C24H29N3O3•2HCl•xH2O分子量： 480.43描述应用纯度储存/保存方法形态外观折射率Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
ARC 239 dihydrochloride hydrate is a selective α2B-AR adrenoceptor antagonist with a pKD value of 8.8. This antagonist is known to display inhibitory effects on α2A-AR (α2A) and α2D receptors with pKD values of 6.7 and 6.4 respectively. Studies indicate that ARC 239 dihydrochloride is 100-fold more selective towards the α2B-AR (α2B adrenoceptor) than chlorpromazine and 7-hydroxychlorpromazine. Studies conducted on pentobarbital-treated dogs and rats show that ARC 239 dihydrochloride competitively antagonizes pressor responses to adrenaline, while inhibiting these pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium. ARC 239 dihydrochloride hydrate is an inhibitor of α2B-AR.
|
| 应用 |
A selective α2B-AR adrenoreceptor antagonist
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at 4° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 外观 |
Powder
|
| 折射率 |
n20D 1.58 (Predicted)
|
| Ki 数据 |
α1A-AR: Ki= 1 nM (human); α2C-AR: Ki= 10 nM (human); α2B-AR: Ki= 10 nM (human)
|
| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and water (100 mM).
|
| MDL |
MFCD16875414
|
| PubChem CID |
10345075
|
CX-6258 hydrochloride hydrateCAS号： 1353858-99-7分子式： C26H27Cl2N3O4分子量： 516.42描述纯度储存/保存方法别名可溶性/溶解性靶点
| 产品描述 | |
| 描述 |
CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
CX6258 hydrochloride hydrate, CX 6258 hydrochloride hydrate
|
| 可溶性/溶解性 |
10 mM in DMSO
|
| 生物活性 | |
| 靶点 |
Pim
|
分子结构图
2,6-二氯酚靛酚钠,2,6-Dichloroindophenol sodium salt hydrate,CAS：620-45-1,货号：D8410-1g
| 市场价： | ￥240.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 1g |
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产品详情
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参考文献
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Morin hydrate 桑色素 标准品
| EC | EINECS 207-542-9 |
| MDL | MFCD00006826 |
| 别名 | 桑黄素;Aluminum Ionophore I; |
| 英文名称 | Morin hydrate |
| CAS | 480-16-0 |
| 分子式 | C15H10O7 |
| 分子量 | 302.24 |
| 储存条件 | 2-8℃ |
| 纯度 | HPLC≥98% |
| 外观（性状） | powder |
| 单位 | 瓶 |
| SMILES | O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=CC(O)=CC(O)=C13 |
| 规格 | 20mg |
本品为分析标准品。