Baccatin Ⅲ；巴卡亭 Ⅲ
货号：
IB0470
品牌：
Jinpan
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产品简介
| MDL | MFCD00153921 |
| 别名 | 巴卡丁III |
| 英文名称 | Baccatin Ⅲ |
| CAS | 27548-93-2 |
| 分子式 | C31H38O11 |
| 分子量 | 586.63 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1]. |
| In Vivo | MDSCs isolated from baccatin III-treated mice, compared with those isolated from vehicle-treated mice, had a significantly reduced suppressive effect on T cells treated with the anti-CD3 and anti-CD28 monoclonal antibodies. Baccatin III reduced tumor progression by inhibiting the accumulation and suppressive function of MDSCs.[1] |
| SMILES | O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](O)C[C@@]2(O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]1(C)[C@@H](O)C[C@@]5([H])OC[C@]54OC(C)=O |
| 靶点 | Others |
| 细胞实验 | Baccatin III, which is the precursor for the semisynthesis of paclitaxel, exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg). Oral administration of baccatin III significantly reduced the growth of tumors induced by engrafting BALB/c mice with either 4 T1 mammary carcinoma or CT26 colon cancer cells. Baccatin III decreased the accumulation of MDSCs in the spleens of the tumor-bearing mice.[1] |
| 数据来源文献 | [1]. Lee YH, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93. |
| 规格 | 5mg 10mM*1mL in DMSO 10mg 20mg |
Baccatin III 能通过减少 MDSCs 积累和抑制其功能，延缓肿瘤发展进程。