Baccatin Ⅲ;巴卡亭 Ⅲ

Baccatin Ⅲ;巴卡亭 Ⅲ

货号:
IB0470

品牌:
Jinpan

Baccatin Ⅲ;巴卡亭 Ⅲ

暂无详情
产品简介
MDL MFCD00153921
别名 巴卡丁III
英文名称 Baccatin Ⅲ
CAS 27548-93-2
分子式 C31H38O11
分子量 586.63
纯度 HPLC≥98%
单位
生物活性 Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1].
In Vivo MDSCs isolated from baccatin III-treated mice, compared with those isolated from vehicle-treated mice, had a significantly reduced suppressive effect on T cells treated with the anti-CD3 and anti-CD28 monoclonal antibodies. Baccatin III reduced tumor progression by inhibiting the accumulation and suppressive function of MDSCs.[1]
SMILES O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](O)C[C@@]2(O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]1(C)[C@@H](O)C[C@@]5([H])OC[C@]54OC(C)=O
靶点 Others
细胞实验 Baccatin III, which is the precursor for the semisynthesis of paclitaxel, exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg). Oral administration of baccatin III significantly reduced the growth of tumors induced by engrafting BALB/c mice with either 4 T1 mammary carcinoma or CT26 colon cancer cells. Baccatin III decreased the accumulation of MDSCs in the spleens of the tumor-bearing mice.[1]
数据来源文献 [1]. Lee YH, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93.
规格 5mg 10mM*1mL in DMSO 10mg 20mg

Baccatin III 能通过减少 MDSCs 积累和抑制其功能,延缓肿瘤发展进程。

Baccatin Ⅲ 巴卡亭 Ⅲ 标准品

Baccatin Ⅲ 巴卡亭 Ⅲ 标准品

货号:
SB8370

品牌:
Jinpan

Baccatin Ⅲ 巴卡亭 Ⅲ 标准品

暂无详情
产品简介
MDL MFCD00153921
别名 巴卡丁III;
英文名称 Baccatin Ⅲ
CAS 27548-93-2
分子式 C31H38O11
分子量 586.63
储存条件 2-8℃
纯度 HPLC≥98%
外观(性状) 白色结晶性粉末
单位
SMILES O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](O)C[C@@]2(O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]1(C)[C@@H](O)C[C@@]5([H])OC[C@]54OC(C)=O
规格 20mg
本品为分析标准品。