诺氟沙星 标准品
| 英文名称 | Norfloxacin |
| CAS | 70458-96-7 |
| 分子式 | C16H18FN3O3 |
| 分子量 | 319.33 |
| 储存条件 | 2-8℃ |
| 规格 | 100mg |
2-苯并唑啉酮
| 有效期 | 2年 |
| 描述 | 是一种抗利什曼原虫试剂。 |
| EC | EINECS 200-430-0 |
| MDL | MFCD00005716 |
| InChIKey | ASSKVPFEZFQQNQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9) |
| PubChem CID | 6043 |
| 别名 | 2-苯并恶唑酮 |
| 英文名称 | 2-Benzoxazolinone |
| CAS | 59-49-4 |
| 分子式 | C7H5NO2 |
| 分子量 | 135.12 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | Light beige Powder |
| 单位 | 瓶 |
| 生物活性 | 2-Benzoxazolinone (BOA), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate.[1] 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[2] |
| IC50 | LC50: 40 μg/mL (L. donovani)[2] |
| In Vitro | BOA induces oxidative stress in mung bean as indicated by increased generation of H2O2, enhanced LP and accumulation of endogenous PRO. It is accompanied by an upregulation of the activities of various scavenging enzymes—SODs, peroxidases, CATs and GR—in roots and leaves of mung bean in response to BOA exposure.[1] The LC50 values for BOA and pentamidine are 40 pg/ml and 39.8 pg/mi, respectively. BOA showed antileishmanial activity and compares well with pentamidine. [2] |
| 激酶实验 | For the BOA treatment, we followed the method used by Burgos and Talbert , wherein seeds germinated on a filter paper disc moistened with BOA and grow until the measurement of seedling length. Seeds of mung bean were surface sterilized with sodium hypochlorite (0.1%, w/v) followed by washing with distilled water three times. These were subjected to germination in 15 cm diameter Petri dishes lined with a Whatman no. 1 filter circle and moistened with 7 ml of respective BOA treatment solution or distilled water (control). The 7 ml of the 0.1, 0.5, 1.0, 2.5, and 5.0 mM BOA solution used cor_x005frespond to nearly 0.0946, 0.473, 0.946, 2.365, 4.73 mg ml–1 BOA, respectively. It was in the range similar to that used by Burgos and Talbert [13]. Twenty-five mung bean seeds were used in each Petri dish. Five replicates were maintained for each treatment in a completely randomized manner. All the Petri dishes were placed in a seed germinator maintained at 25 ± 2 °C, 75 ± 3% relative humidity and a 16 h:8 h light: dark photoperiod with a photosynthetic photon flux density of 150 μmol m–2 s–1. After 7 days, root and shoot length of emerged seedlings from each treatment were measured. Further, roots and leaves from each treatment were harvested and stored at –80 °C prior to enzyme extraction and other estimations.[1] |
| SMILES | O=C1OC2=CC=CC=C2N1 |
| 靶点 | Parasite |
| 细胞实验 | Promastigote para- sites in the stationary phase of growth (1 x io parasite/mi) were inoculated into culture tubes containing BHI-agar as solid part and HBSS as hquid part. To these tubes different concentrations (10 to 100 pg/mi, DMSO/PBS) of BOA and pentamidine were added, respectively. The inhibitory effect of BOA was compared with pentamidine which is known to be active against leishmaniasis, and with untreated control cultures. The whole operation was carried out aseptically in an ultraviolet chamber and the tubes were incubated for 5 days at 22 °C. The toxicity of DMSO was determined by adding different amounts of solvent (0.1 to 1.5%) to suspensions of promastigotes under the conditions described above. After five days the value of the non-toxic dilution was found to be 0.6% and growth inhibition (up to 15%) was observed between 0.6% and 1 %; therefore, higher concentrations of DMSO were never used. Antileishmanial activity of each of the com_x005fpounds was determined by counting the number of live parasites per field microscopically. The LC55 values were calculated by probit analysis and no mortallty was observed in mice when BOA was administered ((p.) in the doses ranging from 0.25—1 g/kg. The mice were kept under observation for one week.[2] |
| 数据来源文献 | [1] Batish D R , Singh H P , Setia N , et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus).[J]. Plant Physiol Biochem, 2006, 44(11-12):819-827. [2]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8. |
| 规格 | 50mg 100mg 250mg |
100ul超低吸附滤芯吸头
| 单位 | 箱 |
| 英文名称 | 100ulMaxymumRecoveryUniversalFitFilteredPipetTips,1000TipsPerUnit.10Units/Case. |
| 规格 | 1000支/包，10包/箱 |
氟罗沙星 标准品
| 英文名称 | Fleroxacin |
| CAS | 79660-72-3 |
| 分子式 | C17H18F3N3O3 |
| 分子量 | 369.34 |
| 储存条件 | 2-8℃ |
| 规格 | 100mg |
SANYO三洋 药品冷藏（MPR-215F(冷藏室)）
药品冷藏、冷冻保存箱
日本三洋 药品冷藏冷冻保存箱主要用于医疗，生物研究，制药以及工业部门，用于提供恒定温度条件的培养测试环境，以检测产品在该环境条件下的稳定性或者在该环境条件下的自发化学或物理性质的变化，或者提供相应恒定的反应环境。
其温度的稳定型和均一性，特别是除霜时的温度稳定性是普通家用冰箱所不能比拟的。
| 商品属性 | |
|---|---|
| 商品名称 | SANYO三洋 药品冷藏（MPR-215F）-MPR-215F-SANYO三洋 |
| 型号 | MPR-215F |
| 类别 | 实验室常用设备|||实验箱体|||低温冰箱|||SANYO三洋药品冷藏（MPR-215F） |
| 品牌 | SANYO三洋 |
| 品牌简介 | SANYO三洋 |
| 关键字 | 低温冰箱 超低温冰箱 超低温冷藏箱 进口低温冰箱,冷藏室,冷冻室,冰箱,药品,环境,超低温 |
(-)-对溴四咪唑草酸盐
| 有效期 | 2年 |
| 描述 | 是强效的非特异性的碱性磷酸酶抑制剂。 |
| MDL | MFCD00070406 |
| EC | EINECS 263-487-0 |
| 别名 | (S)-(-)4-溴四咪唑草酸盐 |
| 英文名称 | (-)-p-Bromotetramisole Oxalate |
| CAS | 62284-79-1 |
| 分子式 | C11H11BrN2S·C2H2O4 |
| 分子量 | 373.22 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to light yellow crystalline Powder |
| 单位 | 瓶 |
| SMILES | BrC1=CC=C([C@@H]2N=C3SCCN3C2)C=C1.O=C(O)C(O)=O |
| 靶点 | Phosphatase |
| 规格 | 5mg 10mg |
培氟沙星 标准品
| 英文名称 | Pefloxacin mesylate dihydrate |
| CAS | 149676-40-4 |
| 分子式 | C17H20FN3O3.CH4OS |
| 分子量 | 465.49 |
| 储存条件 | 2-8℃ |
| 规格 | 100mg |
仪器说明
真空冷冻干燥技术，简称冻干，又称升华干燥。广泛应用于药品、生物制品、化工及食品工业。对热敏性物质如抗生素、疫苗、血液制品、酶激素及其他生物组织，冻干技术非常适用。
主要特点
● 台式设计，紧凑，占用台面小。 ● 外形美观，人体工学设计，操作方便。 ● 原装进口全封闭压缩机，高效可靠，噪音低。● 冷阱开口大，带样品预冻功能。 ● 冷阱为全不锈钢，冷阱内无盘管，光洁耐腐蚀。● 专利设计导流筒，提高冷阱有效面积，快速冻干。● 原装进口充气阀，可充干燥氮气或惰性气体。● 透明钟罩式干燥室，安全直观。 ● 不锈钢样品架，样品盘间距可调。● 国际标准真空接口，可与多种真空泵联用。● 数字显示温度及真空度。● 样品温度显示（可选配）。
技术指标
●冷凝温度： -50℃
●真 空 度：< 20Pa
●冻干面积：0.12㎡
●盘装物料：1.2 升
●捕水能力：3kg/24h
●样 品 盘： Φ200mm×4层
●电源要求：220V 50Hz 850W
●主机尺寸：380×600×345mm
标准配置
台式主机、2升国产真空泵、普通干燥装置 、橡胶阀8只、冻干瓶8只
相关合作单位
中科院生物物理研究所、理化所、遗传所、化学所、协和医科大学基础医学研究所、中国农业科学院、北京医科大学、中国农业大学、 浙江大学、河北医科大学、合肥工业大学、徐州师范大学、中国人民解放军总医院、中国药品生物制品检定所、南开大学、第四军医大学药物研究所、中科院上海硅酸盐研究所、上海化学研究所、中科院长春应用化学所、国家海洋局第三研究所、南京药科大学等
| 商品属性 | |
|---|---|
| 商品名称 | 博医康 冷冻干燥机 FD-1C-50-FD-1C-50-博医康 |
| 型号 | FD-1C-50 |
| 类别 | 实验室常用设备|||温度控制|||冷冻干燥机|||博医康冷冻干燥机FD-1C-50 |
| 品牌 | 博医康 |
| 品牌简介 | 博医康 |
| 关键字 | 国产冷冻干燥机/干燥设备 国产实验室冻干机 实验室冷冻式干燥机 台式压盖型冷冻干燥机,样品,温度,水能,干燥,物料,中科院 |
巴氯芬
| 有效期 | 2年 |
| 描述 | 是一种有效，选择性的代谢型 GABA-B 受体 (GABABR) 激动剂。 |
| EC | EINECS 214-486-9 |
| MDL | MFCD00055143 |
| InChIKey | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
| PubChem CID | 2284 |
| 别名 | 氯苯氨丁酸;氯苯氨酪酸;脊舒锭;力奥来素 |
| 英文名称 | Baclofen |
| CAS | 1134-47-0 |
| 分子式 | C10H12ClNO2 |
| 分子量 | 213.66 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to reddish yellow crystalline Powder |
| 单位 | 瓶 |
| 生物活性 | Baclofen是GABA衍生物，被用作骨骼肌的弛缓药和中枢神经系统抑制剂。它能够激活GABA receptors，尤其是GABAB受体。[2] |
| In Vitro | Baclofen induces G0/G1 phase arrest which is connected with down-regulation of intracellular cAMP level, and up-regulation of p21WAF1 protein expression as well as its phosphorylation level in human hepatocellular carcinoma cell[3]. |
| In Vivo | Chronic treatment with baclofen markedly diminishes hippocampal atrophy and neuronal apoptosis in hippocampal CA1 area via the regulation of autophagy in chronic cerebral hypoperfusion in rats. Baclofen might suppress cytodestructive autophagic activity through Akt-GSK-3β-p-mTOR-Beclin 1 signaling pathway under chronic cerebral hypoperfusion. During brain ischemia, baclofen could reduce CX43 and CX36 surface expression. Baclofen-induced suppression of increased CX43 and CX36 surface expressions helps neurons survive[1]. Baclofen reduces reinstatement to cocaine self-administration in an animal model of relapse[2]. Baclofen suppresses Bel-7402 xenograft tumor growth in vivo[3]. |
| SMILES | O=C(O)CC(C1=CC=C(Cl)C=C1)CN |
| 靶点 | GABA Receptor |
| 动物实验 | Bel-7402, HuH-7, and HepG2 cells are seeded into 96-well plates (10,000 per well) in a final volume of 200 μl medium. After a 24-hour attachment, cells are incubated with Bac (25, 50 and 100 μM) in the absence or presence of Pha (100 μM) for indicated time intervals. During this time, the culture medium is replaced with fresh medium every 24 h. After treatment, cell proliferation is evaluated by MTS assay. The OD values are measured at 490 nm with a microplate spectrophotometer.[3] |
| 细胞实验 | Animal Models: male Sprague-Dawley rats of clean grade, aged 2-3 months, weighing 220-250?g; Dosages: 12.5 mg/kg and 25?mg/kg; Administration: i.p.[1] |
| 数据来源文献 | [1] Li Liu, et al. Scientific Reports. 2015, 5: 14474. [2] Di Ciano P, et al. Neuropsychopharmacology. 2003, 28(3):510-8. [3] Wang T, et al. Life Sci. 2008, 82(9-10):536-41. |
| 规格 | 500mg 1g |
100ul盒装灭菌透明滤芯吸头
| 单位 | 大盒 |
| 英文名称 | 100uLUniversalFitFilterTips,Clear,Sterile,RackPack,96Tips/Rack,10Racks/Pack,5Packs/Case. |
| 规格 | 96支/盒，10盒/大盒，5大盒/箱 |