比克替拉韦

比克替拉韦

货号:
IB2610

品牌:
Jinpan

比克替拉韦

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比克替拉韦

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产品简介
有效期 2年
别名 毕卡特韦;GS-9883
英文名称 Bictegravir
CAS 1611493-60-7
分子式 C21H18F3N3O5
分子量 449.38
储存条件 -20℃
纯度 ≥98%
外观(性状) Powder
单位
生物活性 Bictegravir (GS-9883)是一种新型的、有效的HIV-1 integrase抑制剂。[1]
In Vitro Bictegravir exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes, with 50% effective concentrations ranging from 1.5 to 2.4 nM and selectivity indices up to 8,700 relative to cytotoxicity. Bictegravir inhibits the strand transfer activity with an IC50 of 7.5 ± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 integrase, with an IC50 of 241 ± 51 nM. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ~6,800 in MT-2 cells and ~1,500 in MT-4 cells[1].
SMILES O=C1N([C@](CC2)([H])C[C@]2([H])O3)[C@@]3([H])CN(C=C(C(NCC(C(F)=CC(F)=C4)=C4F)=O)C5=O)C1=C5O
靶点 HIV-1 integrase
数据来源文献 [1] Tsiang M, et al. Antimicrob Agents Chemother. 2016, 60(12):7
规格 5mg 10mg

是一种新型的、有效的HIV-1 integrase抑制剂。