宾达利
货号：
IB2420
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| MDL | MFCD00866723 |
| 别名 | AF-2838 |
| 英文名称 | Bindarit |
| CAS | 130641-38-2 |
| 分子式 | C19H20N2O3 |
| 分子量 | 324.37 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white (Solid) |
| 单位 | 瓶 |
| 生物活性 | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1]. |
| In Vitro | Bindarit (10-300 μM; 48 hours) at 100 μM and 300 μM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively[1]. |
| In Vivo | Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation[2]. |
| SMILES | CC(OCC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)(C)C(O)=O |
| 靶点 | MCP-1/CCL2，MCP-3/CCL7，MCP-2/CCL8 |
| 数据来源文献 | [1]. Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84(3): p. 485-93.
[2]. Zoja C, Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int. 1998 Mar;53(3):726-34. |
| 规格 | 2mg 5mg |
是一种有效且选择性的单核细胞趋化蛋白MCP-1 / CCL2，MCP-3 / CCL7和MCP-2 / CCL8抑制剂。