L-Theanine L-茶氨酸 标准品
| CAS | 3081-61-6 |
| 分子式 | C7H14N2O3 |
| 分子量 | 174.200607 |
| 储存条件 | Store in dry and dark place. |
| 纯度 | HPLC : ≥98% |
| 单位 | 瓶 |
| 货期 | 4周 |
| 规格 | 20mg |
犬尿氨酸 标准品
| MDL | MFCD00069912 |
| 别名 | 色氨酸杂质C |
| 英文名称 | L-Kynurenine |
| CAS | 2922-83-0 |
| 分子式 | C10H12N2O3 |
| 分子量 | 208.22 |
| 储存条件 | 2-8℃ |
| 纯度 | HPLC≥98% |
| 外观（性状） | powder |
| 单位 | 瓶 |
| SMILES | O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O |
| 规格 | 100mg |
L-赖氨酸 标准品
| EC | EINECS 200-294-2 |
| MDL | MFCD00064433 |
| 别名 | L-2,6-二氨基已酸，L-已氨酸，L-松氨酸 |
| 英文名称 | L-Lysine |
| CAS | 56-87-1 |
| 分子式 | C6H14N2O2 |
| 分子量 | 146.19 |
| 储存条件 | RT |
| 纯度 | HPLC≥98% |
| 外观（性状） | Off-white Powder |
| 单位 | 瓶 |
| SMILES | N[C@@H](CCCCN)C(O)=O |
| 规格 | 200mg |
本品为分析标准品。
L-茶氨酸 标准品
| EC | EINECS 221-379-0 |
| MDL | MFCD00059653 |
| 别名 | N-乙基-L-谷氨酰胺 |
| 英文名称 | L-Theamine |
| CAS | 3081-61-6 |
| 分子式 | C7H14N2O3 |
| 分子量 | 174.2 |
| 储存条件 | 2-8℃ |
| 纯度 | HPLC≥98% |
| 外观（性状） | 白色晶体 |
| 单位 | 瓶 |
| SMILES | OC([C@@H](N)CCC(NCC)=O)=O |
| 规格 | 20mg |
L-门冬氨酸 标准品
| 英文名称 | Aspartic Acid |
| CAS | 56-84-8 |
| 分子式 | C4H7NO4 |
| 分子量 | 133.10 |
| 储存条件 | RT,避光 |
| 单位 | 瓶 |
| 规格 | 100mg |
L-犬尿氨酸
| 有效期 | 1月 |
| 描述 | 是一种芳香烃受体 (aryl hydrocarbon receptor) 激动剂。 |
| MDL | MFCD00069912 |
| 别名 | 色氨酸EP杂质C |
| 英文名称 | L-Kynurenine |
| CAS | 2922-83-0 |
| 分子式 | C10H12N2O3 |
| 分子量 | 208.21 |
| 储存条件 | -20℃ |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| In Vivo | 犬尿氨酸通过血管平滑肌中的Kv7通道扩张来自大鼠和人的动脉。在大鼠中，这种色氨酸代谢产物引起低血压，这部分抵消了Kv7通道抑制[2]。在缺氧缺血前1小时施用L-犬尿氨酸显示出剂量依赖性显著的神经保护作用，在300mg / kg的剂量下具有完全保护作用。这种剂量的L-犬尿氨酸也可以阻断大脑皮层中c-fos免疫反应的诱导[3]。 |
| SMILES | O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O |
| 靶点 | Aryl Hydrocarbon Receptor |
| 动物实验 | 大鼠[3]在7日龄大鼠中检查增加剂量的L-犬尿氨酸和/或没有丙磺舒对大脑皮质中犬尿喹啉酸浓度的影响。每组检查六只动物。动物用L-犬尿氨酸以100,200,300和400mg / kg的剂量或犬尿氨酸，200mg / kg用丙磺舒，50mg / kg治疗。在1小时时杀死动物，迅速取出脑，解剖大脑皮层并置于0.5mL冷却的0.1M HCl中。通过具有荧光检测的高效液相色谱法进行犬尿喹啉酸测量。使用荧光测定法进行蛋白质测量[3]。 |
| 细胞实验 | 使用H1L7.5c3细胞进行荧光素酶测定。在指定的时间（0.5,2,4,6,12,18,24小时）和暴露于犬尿氨酸的浓度（0.1,1,10,100μM）下，从孵育中取出细胞并使其平衡至室温。 15分钟。平衡后，除去培养基，在室温下用DPBS洗涤细胞两次。用20μL/孔1×Passive Lysis Buffer裂解细胞，并在室温下振荡20分钟。使用Luminometer Microplate Reader [1]记录荧光素酶活性。 |
| 数据来源文献 | [1]. Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.
[2]. Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7. [3]. Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7. |
| 规格 | 50mg 10mM*1mL in DMSO 100mg |
L-铃兰氨酸
| 有效期 | 2年 |
| 描述 | 是 S-allyl-l-cysteine 的立体异构体，存在于大蒜中，具有免疫调节作用。 |
| EC | EINECS 219-740-2 |
| MDL | MFCD00066660 |
| InChIKey | IADUEWIQBXOCDZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7) |
| PubChem CID | 17288 |
| 别名 | 吖丁啶-2-羧酸 |
| 英文名称 | Azetidine-2-carboxylic Acid |
| CAS | 2517-04-6 |
| 分子式 | C4H7NO2 |
| 分子量 | 101.10 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to Yellow Solid |
| 单位 | 瓶 |
| 生物活性 | Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2]. |
| In Vitro | Administration of azetidine-2-carboxylic acid to growing chick embryos for 5 days produced a marked arrest in the accumulation of collagen and a significant in_x005fcrease in the fragility of the embryos.The effect on collagen in embryos treated with 375 or 500 ~g per day was specific since the decrease in collagen accumulation was consistently over twice the effect on non-collagen proteins. The experiments with cartilage in vitro demonstrated that the principal effect of azetidine-2-carboxylic acid in the first 2 h or so is to increase the intracellular pool of collagen because the collagen containing the analogue cannot be extruded at a normal rate.[3] |
| In Vivo | Autoradiographs from the embryos labeled in vivo indicated that cells treated with azetidine-2-carboxylic acid for 5 days do not adapt to the repeated exposure to the analogue and they still do not extrude collagen containing the analogue at a normal rate. [3] |
| SMILES | O=C(O)C1NCC1 |
| 靶点 | Others |
| 动物实验 | Azetidine-2-carboxylic acid was dissolved in distilled water and 0.2 ml of solution in the appropriate concentration was applied to the air sack of the chick erabryos daily from day 8 to day 12. Control embryos received 0.2 ml of distilled water daily. [14C] Proline or ~3,4-3H21proline was administered by adding the labeled amino acid to the solution of azetidine-2-carboxylic acid or distilled water which was ad_x005fministered to the chick embryos 4-48 h prior to the time the embryos were killed. Femurs and tibiae were removed from the embryo by microscopic dissection.[3] |
| 数据来源文献 | [1]. Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4.
[2]. Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [3]. Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27. |
| 规格 | 100mg 250mg 500mg |
乙氨酸-乙氨酸-酪氨酸-精氨酸 标准品
| MDL | MFCD00076760 |
| 别名 | 甘氨酰甘氨酰酪氨酰-精氨酸;GLYCINE-GLYCINE-TYROSINE-ARGININE;glycyl-glycyl-tyrosyl-arginine; |
| 英文名称 | Gly-Gly-Tyr-Arg |
| CAS | 70195-20-9 |
| 分子式 | C19H29N7O6 |
| 分子量 | 451.48 |
| 储存条件 | -20℃ |
| 纯度 | HPLC≥98% |
| 外观（性状） | Off-white Powder |
| 单位 | 瓶 |
| SMILES | C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)CNC(=O)CN)O |
| 规格 | 20mg |
蒜氨酸 标准品
| EC | Einecs 209-118-9 |
| MDL | MFCD01311056 |
| 别名 | 蒜碱; |
| 英文名称 | Alliin |
| CAS | 556-27-4 |
| 分子式 | C6H11NO3S |
| 分子量 | 177.22 |
| 储存条件 | -20°C |
| 纯度 | HPLC≥98% |
| 外观（性状） | Off-white Powder |
| 单位 | 瓶 |
| SMILES | N[C@@H](C[S@](CC=C)=O)C(O)=O |
| 规格 | 20mg |
用途：A orally acyclic nucleoside
门冬氨酸镁 标准品
| 储存条件 | RT,避光 |
| 规格 | 25mg |