Alfuzosin hydrochloride/SL 77499-10；盐酸阿夫唑嗪
货号：
IA1910
品牌：
Jinpan
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产品简介
| MDL | MFCD00879135 |
| EC | EINECS 620-512-3 |
| 别名 | 阿夫唑嗪盐酸盐;AlfuzosinHCl |
| 英文名称 | Alfuzosin hydrochloride/SL 77499-10 |
| CAS | 81403-68-1 |
| 分子式 | C19H27N5O4·HCl |
| 分子量 | 425.91 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. [1]Alfuzosin is a potent selective alpha1-adrenoceptor antagonist in tissues of the lower urinary tract including the human prostate. This provides a pharmacological basis for its use in the treatment of benign prostatic hypertrophy.[2] |
| In Vitro | Phenylephrine-induced contractions of rabbit isolated trigone and urethra were antagonized in a competitive manner by alfuzosin (pA2 7.44 and 7.30, respectively) and prazosin. [2] |
| In Vivo | In the pithed rat, alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibited pressor responses produced by the alpha 1-selective agonist, cirazoline but inhibited only slightly responses to the alpha 2-selective agonist, UK 14,304. Alfuzosin (1 mg kg-1, i.v.) had minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia).[2] In the anaesthetized cat, alfuzosin (0.001-1 mg kg-1, i.v.) and prazosin (0.001-0.3 mg kg-1, i.v.) produced dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves. [2] |
| SMILES | O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.Cl |
| 靶点 | Adrenergic Receptor |
| 数据来源文献 | [1]. Wilde MI, et al. Alfuzosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in benign prostatic hyperplasia. Drugs. 1993 Mar;45(3):410-29. [2]. Lefèvre-Borg F, O’Connor SE, Schoemaker H, Hicks PE, Lechaire J, Gautier E, Pierre F, Pimoule C, Manoury P, Langer SZ. Alfuzosin, a selective alpha 1-adrenoceptor antagonist in the lower urinary tract. Br J Pharmacol. 1993 Aug;109(4):1282-9. |
| 规格 | 10mg 50mg 100mg |
是α1肾上腺素受体拮抗剂