GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Cross Reactivity:
Human, Bacteria, Mouse, Leech, Pig, Human + Mouse
Animal Free Recombinant Protein AF-300-03 AF-300-03-20 Human GM-CSF 20ug Standard Animal Free Recombinant Protein AF-300-03 AF-300-03-50 Human GM-CSF 50ug Bulk Animal Free Recombinant Protein AF-300-03 AF-300-03-100 Human GM-CSF 100ug Bulk Animal Free Recombinant Protein AF-300-03 AF-300-03-250 Human GM-CSF 250ug Bulk Animal Free Recombinant Protein AF-300-03 AF-300-03-500 Human GM-CSF 500ug Bulk Animal Free Recombinant Protein AF-300-03 AF-300-03-1000 Human GM-CSF 1000ug Bulk
