山姜素
货号：
IA3200
品牌：
Jinpan
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产品简介
| MDL | MFCD00238532 |
| 描述 | 是一种UCK2 抑制剂。 |
| 别名 | 山姜苷;(S)-7-羟基-5-甲氧基黄烷酮 |
| 英文名称 | Alpinetin |
| CAS | 36052-37-6 |
| 分子式 | C16H14O4 |
| 分子量 | 270.28 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities.[1-2] |
| In Vitro | Alpinetin markedly inhibits the LPS- induced TNF-α, IL-6 and IL-1β production both in vitro and vivo. Furthermore, alpinetin blocks the phosphorylation of IκBα protein, p65, p38 and extracellular signal-regulated kinase (ERK) in LPS stimulated RAW 264.7 cells[1]. Alpinetin can suppress the proliferation and invasiveness of GSCs and induce apoptosis in GSCs[2]. |
| In Vivo | Alpinetin attenuates lung histopathologic changes in mouse models[1].The anti-tumor activity of alpinetin was further confirmed in an animal model. Collectively, targeting of GSC by alpinetin is an effective strategy for glioma therapy.[2] |
| SMILES | O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(OC)=C13 |
| 靶点 | UCK2 |
| 动物实验 | Cell viability is evaluated by MTT assay. Briefly, 100 μl cells are plated at a density of 4×105 cells/ml in 96-well plates in a 37 ℃, 5% CO2 incubator for 1 h. Then the cells are treated with 50 μl of alpinetin of different concentrations (0-300 μg/ml) for 1 h, followed by stimulation with 50 μl LPS (4 μg/ml). The total volume of each well is 200 μl, and the concentrations of Alpinetin and LPS are four times diluted finally. After 18 h of LPS stimulation, 20 μl MTT (5 mg/ml) is added to each well, and the cells are further incubated for an additional 4 h. The supernatant is removed and the formation of formazan is resolved with 150 μl/well of DMSO. The optical density is measured at 570 nm on a microplate reader.[1] |
| 细胞实验 | Animal Models: Male BALB/c mice; Dosages: 50 mg/kg; Administration: i.p.[1] |
| 数据来源文献 | [1] Huo M, et al. Int Immunopharmacol. 2012, 12(1):241-8. [2] Wang J, et al. Tumour Biol. 2016, 37(7):9243-8. |
| 规格 | 10mg 20mg |
是一种黄酮类化合物，能够活化 PPAR-γ，具有抗炎活性。
