F3 12道可调移液器 30－300ul
货号：
4660050
品牌：
Thermo
暂无详情
暂无详情
产品简介
| 自动程度 | 手动 |
| 通道数 | 十二道 |
| 消毒方式 | 半支消毒 |
| 量程 | 30-300ul |
日度归档：2024年8月25日
一恒 生化培养箱（液晶屏）（BPC-150F）
一恒 生化培养箱（液晶屏）（BPC-150F）
一恒 生化培养箱（液晶屏）（BPC-150F）-一恒YIHENG-BPC-150F
- 温度范围:0～60℃
- 容积:101～200L
- 品牌属性:国产
实验室常用设备|||实验箱体|||生化培养箱|||一恒生化培养箱（液晶屏）（BPC-150F）
国产/一恒/生化培养箱/生物培养箱/微生物培养箱
一恒 生化培养箱（液晶屏）（BPC-150F）
◆人性化设计
●箱体左侧配有直径为25mm测试孔，可根据放置场所需要而任意布线。
●大屏幕液晶显示，多组数据一屏显示，菜单式操作界面，简单易懂，便于观察和操作。
●采用镜面不锈钢内胆，四角半圆弧过渡，搁板支架可以自由装卸，便于工作室的清洗工作。
●顺应世界环保潮流，全新无氟设计，使您始终走在健康生活的前沿。
●箱内放入振荡器即可进行恒温振荡培养。
◆品质保证
●模糊PID控制器，控温精确波动小，带定时功能，时间最大设定值99小时99分。
●采用国际品牌压缩机和循环风机，独特风道循环系统，保证工作室温湿度均匀。
●多段可编程控制，可以简化复杂的试验过程，真正实现自动控制和运行。（选配）
◆自我诊断功能
●当培养箱发生故障时，液晶显示屏会出现故障信息，运行故障点一目了然。
◆循环风扇速度自动控制
●循环风扇速度大小可自动控制，避免试验过程中由于风量过大造成祥品的挥发。
| 智能化可编程多段控制器（选配） | |
| 可预设15段30步可编程序，每段设置时间1-99小时99分，循环风机转速可调。 | |
| 微电脑程序控制，时间及升温速率，以极快的速度进行加热干燥试验。 | |
| 多段可编程控制，可以简化复杂的试验过程，真正实现自动控制和运行。 | |
| 安全功能（选配） | |
| 独立限温报警系统，超过限制温度即自动中断运行，并声光报警提示操作者。保证实验安全运行不发生意外。 | |
| 温度偏高、偏低和超温将自动报警。 | |
| 方便的数据处理（选配） | |
|
可连接打印机或485通讯接口，具有USB数据转移接口（U盘），用电脑显示，并打印温湿度和时间曲线．为试验过程数据储存与回放提供有力保证。 |
|
| 紫外杀菌系统（选配或霉菌培养箱具有此功能） | |
| 紫外杀菌灯位于箱内后壁，可定期对箱体内部进行消毒，有效杀灭箱体内循环空气中的浮菌，从而有效防止细胞培养期间的污染。 |
商品属性
- 温度范围:0～60℃
- 容积:101～200L
- 品牌属性:国产
| 商品属性 | |
|---|---|
| 商品名称 | 一恒 生化培养箱（液晶屏）（BPC-150F）-BPC-150F-一恒YIHENG |
| 型号 | BPC-150F |
| 类别 | 实验室常用设备|||实验箱体|||生化培养箱|||一恒生化培养箱（液晶屏）（BPC-150F） |
| 品牌 | 一恒YIHENG |
| 品牌简介 | 一恒YIHENG |
| 关键字 | 国产/一恒/生化培养箱/生物培养箱/微生物培养箱,自动控制,箱体,时间,温湿度,速度,过程 |
Human Peroxiredoxin 2（人过氧化物酶2） ELISA KIT
Human Peroxiredoxin 2（人过氧化物酶2） ELISA KIT
货号：BSEH-277-96T
规格：96T
品牌：Biosharp
ELISA KIT又称为ELISA试剂盒、酶联免疫吸附测定试剂盒,是一种灵敏度高,特异性强,重复性好的实验方法,且因其试剂稳定、易保存,操作简便、结果判断客观等已广泛应用在免疫学检验的各领域中,得到全世界科研工作者的认可和应用。
ELISA的基本原理是双抗体夹心法,将样本加入预包被了抗原或抗体的酶标板里,然后再加入酶标记的抗原或抗体,从而固相载体上的抗原或抗体与样品中受检物质的量呈一定的比例。加入酶反应的底物后,底物被酶催化成为有色产物,产物的量与样本中受检物质的量直接相关,故可根据呈色的深浅进行定性或定量分析。
Biosharp ELISA KIT覆盖人、小鼠、大鼠、猪、通用等多种物种,产品达1000多种。每一个产品均经过严格的质检,结果稳定,重复性和线性范围好,特异性和灵敏度高,应用广泛,涉及免疫学、神经学、微生物学、细胞生物学、表观遗传学等多个科学领域。
| 货号 | BSEH-277-96T |
| 规格 | 96T |
| 品牌 | Biosharp |
| 说明书下载 | 点击下载 |
F320-S.aureus HCP ELISA kit F320 金黄色葡萄球菌宿主残留蛋白检测试剂盒-ELISA检测试剂盒
名称：S.aureus HCP ELISA kit
货号：F320
厂家：Cygnus公司
品牌：Cygnus
规格：1 Kit
保存温度：2-8℃
货期：2～5天
详情请。
现货供应，欢迎订购: :
S.aureus HCP ELISA kit
金黄色葡萄球菌宿主残留蛋白检测试剂盒
This kit was developed and validated for use in detecting Staphlococcus aureus HCPs.
相关产品：
Product Catalog # Description
A549 HCP ELISA kit F230 Host cell protein assay, 96 tests
A549 HCP Western Blot Kit F235 Host cell protein assay, 5 mini blots
BHK HCP ELISA Kit F510 Host cell protein assay, 96 tests
Bovine IgG ELISA Kit F070 Bioprocess contaminant assay, 96 tests
Bovine Plasma Protein ELISA Kit F290 Bioprocess contaminant assay, 96 tests
BSA ELISA Kit F030 Bioprocess contaminant assay, 96 tests
Bovine Transferrin ELISA Kit F120 Bioprocess contaminant assay, 96 tests
CHO HCP ELISA Kit F015 Host cell protein assay, 96 tests
CHO HCP Western Blot Kit F060 Host cell protein assay, 5 mini blots
CHO-CM ELISA Kit CM015 Host cell protein assay, 96 tests
CHO-CM Western Blot Kit CM060 Host cell protein assay, 5 mini blots
CHO HCP ELISA Kit, 3G F550 Host cell protein assay, 96 tests
E. coli HCP ELISA Kit F410 Host cell protein assay, 96 tests
E. coli HCP Western Blot Kit F415 Host cell protein assay, 5 mini blots
Goat Casein HCP ELISA Kit F420 Host cell protein assay, 96 tests
Goat IgG ELISA Kit F210 Bioprocess contaminant assay, 96 tests
Total Goat Milk Proteins ELISA kit F240 Host cell protein assay, 96 tests
Total Goat Milk Proteins WB kit F245 Host cell protein assay, 5 mini blots
Human Albumin ELISA Kit F055 Bioprocess contaminant assay, 96 tests
Human IgA ELISA Kit F165 Bioprocess contaminant assay, 96 tests
Human IgG-total ELISA Kit F160 Bioprocess contaminant assay, 96 tests
Human IgM ELISA Kit F170 Bioprocess contaminant assay, 96 tests
HEK 293 HCP ELISA Kit F650 Host cell protein assay, 96 tests
Human Transferrin ELISA Kit F035N Bioprocess contaminant assay, 96 tests
Insect Cell SF9 HCP ELISA Kit F020 Host cell protein assay, 96 tests
Insect Cell SF9 Western Blot Kit F125 Host cell protein assay, 5 mini blots
Insulin ELISA Kit F040 Bioprocess contaminant assay, 96 tests
Lactococcus lactic HCP ELISA Kit F490 Host cell protein assay, 96 tests
Lactococcus lactic HCP WB Kit F495 Host cell protein assay, 5 mini blots
Mouse Total IgG ELISA Kit F049 Bioprocess contaminant assay, 96 tests
Mouse IgG1 ELISA Kit F045 Bioprocess contaminant assay, 96 tests
Mouse IgG2a ELISA Kit F046 Bioprocess contaminant assay, 96 tests
Mouse IgG2b ELISA Kit F047 Bioprocess contaminant assay, 96 tests
Mouse IgM ELISA Kit F090 Bioprocess contaminant assay, 96 tests
MRC5 HCP ELISA Kit F300 Host cell protein assay, 96 tests
NS/0 HCP ELISA kit F220 Host cell protein assay, 96 tests
NS/0 HCP Western Blot kit F225 Host cell protein assay, 5 mini blots
PER.C6 cell line HCP ELISA Kit F530 Host cell protein assay, 96 tests
Pichia pastoris HCP ELISA Kit F140 Host cell protein assay, 96 tests
P.pastoris HCP Western Blot Kit F145 Host cell protein assay, 5 mini blots
Pichia pastoris HCP ELISA Kit, 2nd Generation F640 Antibodies to glycosylation epitopes have been removed and is much more specific than the F140.
Protein A ELISA Kit F050 Bioprocess contaminant assay, 96 tests
Protein A ELISA for human IgG F050H Bioprocess contaminant assay, 96 tests
Protein A ELISA kit F400 Bioprocess contaminant assay, 96 tests
Ps. fluorescens HCP ELISA kit F450 Host cell protein assay, 96 tests
S. cerevisiae HCP ELISA Kit F135 Host cell protein assay, 96 tests
S. cerevisiae HCP Western Blot Kit F130 Western Blot assay, 5 mini blots
SP 2/0 HCP ELISA Kit F180 Host cell protein assay, 96 tests
SP 2/0 HCP Western Blot Kit F185 Western Blot assay, 5 mini blots
S.aureus HCP ELISA Kit F320 Host cell protein assay, 96 tests
Ultra-Sensitive Insulin ELISA Kit F280 Bioprocess contaminant assay, 96 tests
Vero cell HCP ELISA kit F500 Host cell protein assay, 96 tests
Polyclonal Antisera
A549 HCP A549 Goat, neat serum
A549 HCP A549-PA Goat, IgG fraction
A549 HCP A549-AF Goat, affinity purified
Bovine Plasma Proteins BPP04 Rabbit, neat serum
Bovine Plasma Proteins BPP04-PA Rabbit, IgG fraction
Bovine Plasma Proteins BPP04-AF Rabbit, affinity purified
BHK HCP BHK1107 Goat, neat serum
BHK HCP BHK1107-PA Goat, IgG fraction
BHK HCP BHK1107-AF Goat, affinity purified
Campylobacter species 9-25B-PA Rabbit, IgG fraction
Campylobacter species 9-61A Guinea Pig, neat serum
Chlamydia species 8-29A Rabbit, neat serum
Chlamydia species 8-29A-PA Rabbit, IgG fraction
Chlamydia species 8-48 Guinea Pig, neat serum
CHO HCP C0016 Goat, neat serum
CHO HCP C0016-PA Goat, IgG fraction
CHO HCP C0016-AF Goat, affinity purified
CHO-CM HCP M0016 Goat, neat serum
CHO-CM HCP M0016-PA Goat, IgG fraction
CHO-CM HCP M0016-AF Goat, affinity purified
CHO HCP 3G 3G-0016 Goat, neat serum
CHO HCP 3G 3G-0016PA Goat, IgG fraction
CHO HCP 3G 3G-0016AF Goat, affinity purified
Cytomegalovirus 8-21B Rabbit, neat serum
Cytomegalovirus 8-53A Guinea Pig, neat serum
E. coli HCP F117 Goat, neat serum
E. coli HCP F117-PA Goat, IgG fraction
E. coli HCP AP117 Goat, affinity purified
Haemophilus influenzae 8-21A Rabbit, neat serum
Haemophilus influenzae 8-21A-PA Rabbit, IgG fraction
Haemophilus influenzae 8-53B Guinea Pig, neat serum
Haemophilus influenzae 8-53B-PA Guinea Pig, IgG fraction
HEK 293 HCP HK293 Goat, neat serum
Herpes Simplex Virus 8-25A Rabbit, neat serum
Herpes Simplex Virus 8-25A-PA Rabbit, IgG fraction
Herpes Simplex Virus 8-40B Guinea Pig, neat serum
Klebsiella pneumoniae, Genus 9-01 Rabbit, neat serum
Lactococcus lactic HCP LL5557 Goat, neat serum
Lactococcus lactic HCP LL5557-PA Goat, IgG fraction
Lactococcus lactic HCP LL5557-AF Goat, affinity purified
MRC5 HCP MRC5 Goat, neat serum
MRC5 HCP MRC5-PA Goat, IgG fraction
MRC5 HCP MRC5-AF Goat, affinity purified
Mycobacterium genus 8-27B Rabbit, neat serum
Mycobacterium genus 1-04-PA Guinea Pig, IgG fraction
Neisseria meningitidis 8-24B Rabbit, neat serum
Neisseria meningitidis 8-36 Guinea Pig, neat serum
NS/0 HCP N9192 Goat, neat serum
NS/0 HCP N9192-PA Goat, IgG fraction
NS/0 HCP N9192-AF Goat, affinity purified
PER.C6 cell line HCP PC118 Goat, neat serum
PER.C6 cell line HCP PC118-PG Goat, IgG fraction
PER.C6 cell line HCP PC118-AF Goat, affinity purified
Pichia pastoris HCP PI-49 Goat, neat serum
Pichia pastoris HCP PI-49PA Goat, IgG fraction
Pichia pastoris HCP PI-49AF Goat, affinity purified
Pichia pastoris HCP PI-49AF-B Goat, affinity purified-biotinylated
Pichia Pastoris HCP PI-49AF-AP Goat, affinity purified-alk. phosphatase
Pseudomonas fluorescens 7-04 Goat, neat serum
Pseudomonas fluorescens 7-04PA Goat, IgG fraction
Pseudomonas fluorescens 7-04AF Goat, affinity purified
Pseudomonas species 8-57 Guinea Pig, neat serum
Saccharomyces cerevisiae HCP 82-SC Goat, neat serum
Saccharomyces cerevisiae HCP 82SC-PA Goat, IgG fraction
Saccharomyces cerevisiae HCP 82SC-AF Goat, affinity purified
Shigella species 9-03-PA Rabbit, IgG fraction
Shigella species 9-04 Rabbit, neat serum
SF9 HCP 12-SF9 Rabbit, neat serum
SF9 HCP 12-SF9-PA Rabbit, IgG fraction
SF21 HCP 34-SF21 Rabbit, neat serum
SF21 HCP 34-SF21-PA Rabbit, IgG fraction
SP2/0 HCP SP110 Goat, neat serum
SP2/0 HCP SP110-PA Goat, IgG fraction
SP2/0 HCP SP110-AF Goat, affinity purified
SP2/0 HCP SP110AF-B Goat, affinity purified-biotinylated
SP2/0 HCP SP110AF-AP Goat, affinity purified-alk. phosphatase
S. aureus HCP SA8114 Goat, neat serum
S. aureus HCP SA8114-AF Goat, affinity purified
Streptococcus pneumoniae 8-31B Rabbit, neat serum
Streptococcus pneumoniae 8-42A Guinea Pig, neat serum
Streptococcus pneumoniae 8-43A-PA Guinea Pig, IgG fraction
Total Goat Milk Proteins 4042 Rabbit, neat serum
Total Goat Milk Proteins 4042-PA Rabbit, IgG fraction
Total Goat Milk Proteins 4042-AF Rabbit, affinity purified
Vero cell HCP VC807 Goat, neat serum
Vero cell HCP VC807-PA Goat, IgG fraction
Vero cell HCP VC807-AF Goat, affinity purified
Stab-ELISA-rÔ Enzyme Conjugate Diluent/Stabilizers
Alkaline Phosphatase I-045 500mL
Alkaline Phosphatase I-040 1000mL
Alk Phos w/ HAMA blocker I-045H 500mL
Alk Phos w/ HAMA blocker I-040H 1000mL
Horseradish Peroxidase I-035 500mL
Horseradish Peroxidase I-030 1000mL
HRP w/ HAMA blocker I-035H 500mL
HRP w/ HAMA blocker I-030H 1000mL
Liquid Substrates
PNPP Liquid Substrate F008 For use with Alk Phos in ELISA, 100mL
PNPP Liquid Substrate F10008 For use with Alk Phos in ELISA, 1L
TMB Liquid Substrate F027 For use with HRP in ELISA, 100mL
TMB Liquid Substrate F100027 For use with HRP in ELISA, 1L
TMB Liquid Substrate F129 For use with HRP in Western Blot, 100mL
TMB Liquid Substrate F100029 For use with HRP in Western Blot, 1L
BCIP/NBT Liquid Substrate F064 For use with Alk Phos in WB, 1 reagent, 100mL
BCIP/NBT Liquid Substrate F00064 For use with Alk Phos in WB, 1 reagent, 1L
Sample Dilution Buffers
Sample Dilution Buffer, 1L， 100mL, 500mL I028 I028-100 I028-500 For use with BHK, E.coli, CHO, CHO-CM, Human IgG's, HSA, hTransferrin, HEK 293, Insulin, L.lactic, Mouse IgG's, Pichia pastoris, S.cerevisiae, Protein A, Vero cell ELISA kits
A549 Sample Diluent, 100mL , 500mL F233A-100 F233A-500 For use with A549 HCP ELISA kit
BSA Sample Dilution Buffer, 1L , 100mL , 500mL F031A / F031A-100 / F031A-500 For use with BSA, Bovine IgG, Bovine Plasma Proteins and Bovine Transferrin ELISA kits
Goat IgG Dilution Buffer, 1L , 100mL , 500mL F213A /F213A-100 / F213A-500 For use with Goat IgG ELISA kit
Goat Milk Diluent Buffer, 1L , 100mL r, 500mL F243A /F243A-100 /F243A-500 For use with Goat Milk Proteins ELISA kit
NS/0 Sample Dilution Buffer, 1L ，100mL ，500mL F223A / F223A-100 /F223A-500 For use with NS/0 HCP ELISA kit
SP2/0 Sample Dilution Buffer, 1L , 100mL , 500mL F183A / F183A-100 / F183A-500 For use with SP2/0 HCP ELISA kit
Immunogenicity Products
Passive Coated Immunogenicity Kit IM10 Kit for immunogenicity testing
Biotinylated Antigen Coated Immunogenicity Kit IM20 Kit for immunogenicity testing
Biotinylation Kit IM30
Human Immunoglobulin Screening Kit IM40 Kit for immunogenicity testing
Human IgG Subclass Kit IM50 Kit for immunogenicity testing
Substrate Kit IM109 TMB & Stop Solution for ELISA, 50mL
Coatingate Buffer, 1L IM101 For immunogenicity testing
Conjugate Diluent, 1L IM103 For immunogenicity testing
Conjugate Diluent, 500mL IM103-500 For immunogenicity testing
Sample Diluent, 500mL IM104 For immunogenicity testing
FG Blocker, 1L IM107 For immunogenicity testing
BSA Antigen, 1mg/mL IM112 For immunogenicity testing
Bovine IgG Antigen, 1mg/mL IM113 For immunogenicity testing
Bovine Transferrin Antigen, 1mg/mL IM114 For immunogenicity testing
CHO HCP Antigen, 1mg/mL IM115 For immunogenicity testing
E. coli HCP Antigen, 1mg/mL IM116 For immunogenicity testing
Goat IgG Antigen, 1mg/mL IM117 For immunogenicity testing
HSA Antigen, 1mg/mL IM118 For immunogenicity testing
Human IgD Antigen, 1mg/mL IM141 For immunogenicity testing
Human Transferrin Antigen, 1mg/mL IM119 For immunogenicity testing
Insulin Antigen, 1mg/mL IM121 For immunogenicity testing
Mouse IgG Antigen, 1mg/mL IM122 For immunogenicity testing
NS/0 HCP Antigen, 1mg/mL IM123 For immunogenicity testing
SP2/0 HCP Antigen, 1mg/mL IM125 For immunogenicity testing
Gyros Kits-discontinued
CHO 3G HCP G550 For use on the Gyros xP workstation, 560 tests
CHO 3G HCP G550-1 For use on the Gyros xP workstation, 112 tests
E.coli HCP G410 For use on the Gyros xP workstation, 560 tests
E.coli HCP G410-1 For use on the Gyros xP workstation, 112 tests
Protein A G400 For use on the Gyros xP workstation, 560 tests
Protein A G400-1 For use on the Gyros xP workstation, 112 tests
DNA Kits
DNA Extracton in Wells D100W 96 tests in a deep well microtiter plate
DNA Extraction in Tubes D100T 50 tests in microfuge tubes
Residual CHO Host Cell kit in Wells D550W 96 tests in a deep well microtiter plate
Residual CHO Host Cell kit in Tubes D550T 50 tests in microfuge tubes
CHO Amplification kit in Wells D555W 96 tests in a deep well microtiter plate
CHO Amplification kit in Tubes D555T 50 tests in microfuge tubes
Residual Ecoli Host Cell kit in Wells D410W 96 tests in a deep well microtiter plate
Residual Ecoli Host Cell kit in Tubes D410T 50 tests in microfuge tubes
E.coli Amplification kit in Wells D415W 96 tests in a deep well microtiter plate
E.coli Amplification kit in Tubes D415T 50 tests in microfuge tubes
Residual NS/0 Host Cell kit in Wells D220W 96 tests in a deep well microtiter plate
Residual NS/0 Host Cell kit in Tubes D220T 50 tests in microfuge tubes
Miscellaneous Reagents & Components
Deep Well Extraction Plate w/Sealing Mat D102 5 plates
DNA Extraction Buffer for use in tubes D108 30mL
DNA Extraction Buffer for use in wells D105 30mL
DNA Sample Diluent D006-100 100mL
DNA Sample Diluent D006-500 500mL
DNA Sample Diluent D006-1000 1L
DNA TE Buffer, 1L D001 1L
CHO DNA Concentrate D552 10ug/mL, 1mL
E.coli DNA Concentrate D412 10ug/mL, 1mL
NS/0 DNA Concentrate D222 10ug/mL, 1mL
更多详情请来电: :
色瑞替尼
色瑞替尼
货号：
IC2550
品牌：
Jinpan
暂无详情
产品简介
| 有效期 | 2年 |
| 描述 | 是一种有效的ALK抑制剂。 |
| EC | EINECS 811-457-8 |
| MDL | MFCD26142648 |
| 别名 | LDK-378;赛瑞替尼 |
| 英文名称 | Ceritinib |
| CAS | 1032900-25-6 |
| 分子式 | C28H36ClN5O3S |
| 分子量 | 558.14 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off white Solid |
| 单位 | 瓶 |
| 生物活性 | Ceritinib (LDK378) 是有效且特异性的 ALK 抑制剂，IC50 为 0.2 nM。[1-3] |
| IC50 | 0.2 nM (ALK); 7 nM (InsR); 8 nM (IGF-1R); 23 nM (STK22D); 60 nM (FLT3); 260 nM (FGFR2)[1] |
| In Vitro | Ceritinib（LDK378）也抑制RET（IC50 = 400 nM），FGFR3（IC50 = 430 nM），LCK（IC50 = 560 nM），JAK2（IC50 = 610 nM），极光（IC50 = 660 nM），LYN（50 = 840 nM），EGFR（IC50 = 900 nM）和FGFR4（IC50 = 950 nM）[1]。 Ceritinib（LDK378）保留了对ALK酶活性的高效力，IC50值为200pM，并且仅显示出对46种激酶组中IGF-1R，InsR和STK22D的强抑制，最小选择性为70倍。在用各种激酶转染的Ba / F3细胞中，Ceritinib抑制ALK活性，IC50值为40.7nM，并且对所有其他测试的激酶具有> 100nM的IC 50值。 Ceritinib（LDK378）显示出有效的抗增殖活性，在载有NPM-ALK融合基因的Karpas 299人非霍奇金氏Ki阳性大细胞淋巴瘤中IC50值为22.8 nM，在用NPM-ALK融合转染的Ba / F3细胞中为26 nM基因。 Ceritinib对野生型Ba / F3细胞（IC50>2μM）和用Tel-InsR基因转染的Ba / F3细胞（IC50 = 320 nM）也表现出良好的选择性[2]。 |
| In Vivo | Ceritinib（LDK378）在啮齿动物和非啮齿动物中具有优异的药代动力学特征，口服生物利用度> 50％。 Ceritinib显示剂量依赖性肿瘤生长抑制并且在每天施用的Karpas 299大鼠异种移植模型中实现部分肿瘤消退，但是能够在携带EML4-ALK融合基因的H2228 NSCLC大鼠异种移植模型中实现完全肿瘤消退。在两种模型中，Ceritinib（LDK378）在动物中具有良好的耐受性。 Ceritinib（LDK378）进一步评估其ADME谱，发现在肝微粒体中具有相对良好的代谢稳定性，适度的CYP3A4抑制，在hERG膜片钳实验中一些hERG抑制，IC50值为46μM，但没有QTc证据狗和猴遥测研究中的延长[2]。 |
| SMILES | CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3 |
| 靶点 | ALK |
| 动物实验 | 在小鼠，大鼠，狗和食蟹猴中进行体内PK研究。塞立替尼（LDK378）（HCl盐）通过尾静脉以5mg / kg（n = 3）静脉内施用于雄性Balb / c小鼠，并通过管饲法以20mg / kg（n = 3）口服。通过使用相同的制剂，Ceritinib（LDK378）（HCl盐）通过尾静脉以3mg / kg（n = 3）静脉内给予Sprague-Dawley大鼠，并通过管饲法以10mg / kg（n = 3）口服给药。 ）。在给药后24小时内按预定时间连续收集血液样品。雄性比格犬分别接受单次静脉内（n = 2）或口服（n = 3）剂量的Ceritinib（磷酸盐）作为5mg / kg的静脉内溶液和20mg / kg的口服悬浮液。雄性食蟹猴接受单次静脉内（n = 2）或口服（n = 3）剂量的Ceritinib（游离碱）作为5mg / kg的静脉内溶液和60mg / kg的口服悬浮液。在给药后144小时，在预定时间收集血浆的血液样品[1]。 |
| 数据来源文献 | [1]. Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl [2]. Chen J, et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013 Jul 25;56(14):5673-4. [3]. Tucker ER, et al. Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma. Mol Oncol. 2017 Aug;11(8):996-1006. |
| 规格 | 5mg 10mg |
加厚丁腈手套 S号
加厚丁腈手套 S号
货号：
DJS001-3-P
品牌：
扬子
产品简介
| 单位 | 盒 |
| 规格 | 100只/盒 |
利赛膦酸钠 标准品
利赛膦酸钠 标准品
货号：
YZ-100613
品牌：
中检所
产品简介
| 规格 | 100mg |
别名：1-羟基-2-(3-吡啶基)乙叉-1,1-双膦酸钠;利塞膦酸钠;利塞膦酸羟甲烷磺酸钠;[1-Hydroxy-2-(3-Pyridinyl)Ethylidene]-Bis[Phosphonic Acid] Monosodium Salt;Risedremate Sodium;Risedronate Sodium;Sodium Risedronate;(1-Hydroxy-2-(3-Pyridinyl
Desonide Impurities Mixture
Desonide Impurities Mixture
货号：
YZ-1173315
品牌：
美国USP
产品简介
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 25mg |
维科ZW-800D全封闭智能匀浆仪
维科ZW-800D全封闭智能匀浆仪
维科ZW-800D全封闭智能匀浆仪-维科-ZW-800D
- 功率:300W
- 转速:1000-10000转/分
- 品牌属性:国产
生命科学仪器|||微生物学|||匀浆仪|||维科ZW-800D全封闭智能匀浆仪
全封闭智能匀浆仪
维科ZW-800D全封闭智能匀浆仪 性能特点
1、适合高温湿热灭菌；
2、轴承加耐磨密封圈密封；
3、转速和定时均可根据需要调节；
4、十字刀片设计，匀浆均匀，实用性强；
5、整机为不锈钢，经抛光处理，方便清洁；
6、搅拌刀和杯体一体化设计，保证密闭无泄漏；
7、制备供试液快速，减轻工作强度，检品适用范围大；
工作原理
供试品（固体、液体、油剂等）通过匀浆杯内高速旋转的刀片
（搅拌刀、研磨刀、匀浆刀、绞肉刀的研磨、搅拌，达到粉碎、均质和乳化的效果。
适用范围
制药行业；保健品、化妆品；
食品行业；化工行业；
商品属性
- 功率:300W
- 转速:1000-10000转/分
- 品牌属性:国产
| 商品属性 | |
|---|---|
| 商品名称 | 维科ZW-800D全封闭智能匀浆仪-ZW-800D-维科 |
| 型号 | ZW-800D |
| 类别 | 生命科学仪器|||微生物学|||匀浆仪|||维科ZW-800D全封闭智能匀浆仪 |
| 品牌 | 维科 |
| 品牌简介 | 维科 |
| 关键字 | 全封闭智能匀浆仪,匀浆,维科,转速,适用范围,智能,刀片 |
Wash Solution II (concentrated) for GeneJET Plasmid Maxiprep Kit (K0491/K0492)
Wash Solution II (concentrated) for GeneJET Plasmid Maxiprep Kit (K0491/K0492)
货号：
R1621
品牌：
MBI
产品简介
| 单位 | 支 |
| 规格 | 180ml |
应用：DNA&基因组测序分析、PCR