盐酸氨溴索杂质D{顺式-4-[(2-氨基-3,5-二溴苯基]氨基]环己醇盐酸盐} 标准品
| 英文名称 | cis-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride |
| CAS | 107814-37-9 |
| 储存条件 | RT,避光 |
| 规格 | 50mg |
4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
| MDL | MFCD00348720 |
| 别名 | RAD51-stimulatorycompound1 |
| 英文名称 | RS-1 |
| CAS | 312756-74-4 |
| 分子式 | C20H16Br2N2O3S |
| 分子量 | 524.23 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| In Vitro | RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy[1]. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos[2]. |
| 激酶实验 | Briefly, 15 μL reaction volumes include a DNA strand exchange protein (0.8 μM) that is preincubated for 5 min at 37°C with 1 μM (nucleotide concentration) 32P-labeled oligonucleotide 306.7 in a reaction buffer containing 20 mM Hepes (pH 7.5), 1 mM DTT, 2 mM nucleotide cofactor, and 1 mM MgCl2 and various concentrations of RS-1. For experimental buffer conditions that included calcium, 1 mM CaCl2 is present in addition to (in the case of hRAD51) or in the place of (in the case of RecA and scRAD51) the 1 mM MgCl2. Conditions with scRAD51 additionally contains 110 nM scRAD54. After this initial binding reaction, 10 μL of 19.75 μM (base pair concentration) supercoiled homologuecontaining target plasmid DNA (pRS306) is next added along with sufficient magnesium acetate to give a final concentration of 10 mM[1]. |
| 货期 | 1-2天 |
| SMILES | O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2 |
| 靶点 | RAD51 |
| 数据来源文献 | [1]. Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53. [2]. Song J, et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548. |
| 规格 | 5mg 10mM*1mL (in DMSO) 10mg |
RS-1 是一种 RAD51 的激活剂，同时可增强 CRISPR/Cas9 的活性。
盐酸溴己新杂质 I（N-甲基-N-环己基-2-氨基-5-氯-3-溴苯甲胺）
| 英文名称 | Bromhexine Hydrochloride Impurity I（3-bromo-5-chloro-1-((cyclohexyl( methyl)amino)methyl)aniline） |
| CAS | 32193-43-4 |
| 储存条件 | RT |
| 单位 | 瓶 |
| 规格 | 30mg |
N-甲基-N-环己基-2-氨基-5-溴苯甲胺盐酸盐（盐酸溴己新杂质 D）
| 英文名称 | Bromhexine Hydrochloride Impurity D |
| 储存条件 | RT |
| 单位 | 瓶 |
| 规格 | 20mg |
盐酸氨溴索杂质A(2-氨基-3,5-二溴苯甲醇) 标准品
| 英文名称 | (2-Amino-3,5-dibromophenyl)methanol |
| 储存条件 | RT,避光 |
| 规格 | 50mg |
2-氨基-3,5-二溴苯甲醛 标准品
| 英文名称 | 2-Amino-3,5-Dibromobenzaldehyde |
| CAS | 50910-55-9 |
| 分子式 | C7H5Br2NO |
| 分子量 | 278.93 |
| 储存条件 | RT |
| 规格 | 50mg |
马来酸溴苯那敏
| 有效期 | 2年 |
| EC | EINECS 213-562-9 |
| MDL | MFCD00057367 |
| 别名 | 溴苯吡胺马来酸盐；溴米索伐杂质 |
| 英文名称 | Brompheniramine Hydrogen Maleate |
| CAS | 980-71-2 |
| 分子式 | C16H19BrN2·C4H4O4 |
| 分子量 | 435.31 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white Powder |
| 单位 | 瓶 |
| SMILES | CN(C)CCC(C1=CC=C(Br)C=C1)C2=NC=CC=C2.O=C(O)/C=CC(O)=O |
| 靶点 | Histamine Receptor |
| 规格 | 50mg 100mg |
AK-7；N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
| MDL | MFCD03140195 |
| InChIKey | IYAYHZZWYNXHEQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23) |
| PubChem CID | 1328033 |
| 别名 | N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺 |
| CAS | 420831-40-9 |
| 分子式 | C19H21BrN2O3S |
| 分子量 | 437.35 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| SMILES | O=S(N1CCCCCC1)(C2=CC(C(NC3=CC(Br)=CC=C3)=O)=CC=C2)=O |
| 靶点 | SIRT2 |
| 规格 | 5mg 10mg |