2,3-Butanedione 2-MonoximeCAS号： 57-71-6分子式： C25H52NO4P分子量： 461.66描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction.
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| 纯度 |
＞99%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
2,3-丁烷二酮一肟；二乙酰一肟；NSC 660；NSC 116103
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| 外观 |
白色至类白色结晶性粉末
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| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
skeletal muscle myosin-II
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| In vitro(体外研究) |
BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels.
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| In vivo(体内研究) |
BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation.
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| 参考文献 | |
| 参考文献 |
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分子结构图
