GLP-1 (7-37)CAS号： 106612-94-6分子式： C151H228N40O47分子量： 3355.74描述序列纯度储存/保存方法注意事项别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
GLP-1 (7-37) Acetate is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells. It is a potent insulinotropic hormone. |
| 序列 |
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
|
| 纯度 |
95%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 注意事项 |
该产品以醋酸盐的形式提供
|
| 基本信息 | |
| 别名 |
人胰高血糖素样肽-1; GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat)
|
| 外观 |
White Lyophilized powder
|
| 可溶性/溶解性 |
Soluble in water at 2mg/ml
|
| 生物活性 | |
| 靶点 |
Glucagon Receptor
|
| In vivo(体内研究) |
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion. An intravenous (IV) infusion of GLP-1(7-37) at 0.5, 5, or 50 pmol/min/kg during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp in Sprague-Dawley rats produces a dose-related enhancement of the glucose-induced increase in plasma insulin concentration. Infusion of GLP-1(7-37) (5 pmol/min/kg IV) during a hyperglycemic clamp at two sequentially increasing concentrations of glucose, 11 and 17 mmol/L, produces incremental increases in insulin of 600 and 1,200 pM, respectively. Similarly, infusion of GLP-1(7-37) in hyperinsulinemic, hyperglycemic Zucker diabetic fatty (ZDF) rats produces a transitory increase in plasma insulin concentration and normalizes the plasma glucose concentration. Infusion of GLP-1(7-37) in rats maintains at 11 mM glucose results in a sustained approximately twofold enhancement of the plasma insulin concentration. In rats infused with GLP-1(7-37) for 5 days at 15 pmol/min/kg, there is a small increase in basal plasma insulin concentration and no effect on glucose.
|
分子结构图
