四烯甲萘醌 标准品
| MDL | MFCD00079646 |
| 别名 | 维生素K2(20) |
| 英文名称 | Menatetrenone |
| CAS | 863-61-6 |
| 分子式 | C31H40O2 |
| 分子量 | 444.65 |
| 储存条件 | -20℃，密封，避光 |
| 纯度 | HPLC≥98% |
| 外观（性状） | Off-white Powder |
| 单位 | 瓶 |
| SMILES | O=C1C(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)C)C(C2=C1C=CC=C2)=O |
| 规格 | 20mg |
四烯雌酮
| MDL | MFCD00867855 |
| EC | EINECS 212-703-1 |
| 别名 | 烯丙基群勃龙; 硫酸金刚烷胺 |
| 英文名称 | Altrenogest |
| CAS | 850-52-2 |
| 分子式 | C21H26O2 |
| 分子量 | 310.43 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Treatment of embryo-recipient mares with altrenogest appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. Altrenogest treatment also seems to be conductive to pregnancy maintenance in recipients experiencing luteal dysfunction.[1] |
| In Vitro | Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with Altrenogest (Allyltrenbolone) appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer[1]. The oil and gel Altrenogest (Allyltrenbolone) preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest (Allyltrenbolone) treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL[2]. |
| SMILES | C[C@]([C@]1(O)CC=C)(C=C2)[C@](CC1)([H])[C@@](CC3)([H])C2=C(CC4)C3=CC4=O |
| 靶点 | Progesterone Receptor |
| 细胞实验 | The response to 15-d altrenogest treatment (Experiment 1) was characterized in 20 mares that were given 22 mg daily of altrenogest in oil (n = 10) or in gel (n = 10) from Day 10 to 25 after ovulation. [2] |
| 数据来源文献 | [1]. Parry-Weeks, L.C. and D.W. Holtan, Effect of altrenogest on pregnancy maintenance in unsynchronized equine embryo recipients. J Reprod Fertil Suppl, 1987. 35: p. 433-8. [2]. Daels, P.F., et al., Persistence of the luteal phase following ovulation during altrenogest treatment in mares. Theriogenology, 1996. 46(5): p. 799-811. |
| 规格 | 50mg 100mg |
是一种孕激素，结构与trenbolone相关，能作用于孕激素受体。
Menatetrenone；四烯甲萘醌
| MDL | MFCD00079646 |
| 别名 | 维生素K2 |
| 英文名称 | Menatetrenone |
| CAS | 863-61-6 |
| 分子式 | C31H40O2 |
| 分子量 | 444.65 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Menaquinone-4 是一种维生素 K，用作一种止血剂，用于治疗骨质疏松的辅助治疗。[1-2] |
| In Vitro | 甲基萘醌-4（MK-4,0,1,5,10μM）增加Caco-2细胞中的ALP活性。甲基萘醌-4（1μM）显著增加hSI表达的强度[1]。 |
| In Vivo | HF-K2组中的甲基萘醌-4（K2,0.2g/kg饮食）在C57BL/6J小鼠中产生附睾脂肪，并且还增加小鼠的骨密度[2]。 |
| SMILES | O=C1C(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)C)C(C2=C1C=CC=C2)=O |
| 靶点 | Others |
| 动物实验 | 42只雄性，4周龄的C57BL/6J小鼠随意提供饲料和饮料。对于环境适应，动物有1周的循环，然后在随机分成6组（每组7只动物;随机区组设计）后提供实验饮食。 AIN-93G饮食包括正常饮食（N），正常饮食+维生素K1（N-K1），正常饮食+维生素甲萘醌-4（N-K2），45％高脂饮食（HF），45％高脂肪饮食+维生素K1（HF-K1），45％高脂饮食+维生素甲萘醌-4（HF-K2）。维生素K1和维生素甲基萘醌-4含量为200mg/1,000g，饮食以颗粒形式提供。每周测量一次体重，并且通过将实验期间的食物摄入量除以第1天至最后一天的增加的体重来计算食物效率比（FER）。对于脂肪量测量，从死亡动物受试者中提取附睾脂肪，肾周脂肪和腹膜后脂肪，用0.9％NaCl洗涤，用滤纸干燥，然后称重[2]。 |
| 细胞实验 | 将Caco-2细胞以2-5×10 4个细胞/ cm 2的密度接种到35-mm培养皿上。将细胞温育2至3天直至60％-70％汇合，并加入所需浓度的甲基萘醌-4（0,1.0,5.0和10.0μM）。载体的最终浓度为培养基的0.1％，培养基每周更换两次。在添加Menaquinone-4 [1]后第0,3,7和11天测定细胞。 |
| 数据来源文献 | [1]. Noda S, et al. Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells. Nutr Res. 2016 Nov;36(11):1269-1276. [2]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. |
| 规格 | 20mg 10mM*1mL in DMSO |
四烯甲萘醌又称维生素K2，是一种含有甲萘醌基本结构并具有抗出血作用的天然存在的维生素。