Wnt agonist 1CAS号： 853220-52-7分子式： C19H18N4O3分子量： 350.37描述应用纯度储存/保存方法别名外观可溶性/溶解性靶点
| 产品描述 | |
| 描述 |
Wnt Agonist is a cell-permeable pyrimidine compound that acts as, at an IC50 > 60 μM, a potent and selective activator of Wnt signaling. In addition to mimicking the effect of Wnt, Wnt Agonist has also induced β-catenin and T-cell fate-dependent transcriptional activity in HEK-293T cells at an EC50 = 700 nM. When applied to Xenopous embryos Wnt Agonist caused substantial head defects development. Wnt Agonist has also been observed to enhance beta cell expansion in vitro. The compound is beneficial for studying the effects of Wnt pathway due to the activation of Wnt without inhibiting the activity of GSK-3β. |
| 应用 |
A potent and selective activator of Wnt signaling
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
BML-284
|
| 外观 |
Yellowish sticky solid
|
| 可溶性/溶解性 |
DMSO : ≥ 100 mg/mL (285.41 mM)
|
| 生物活性 | |
| 靶点 |
Wnt/β-catenin
|
分子结构图
