邻苯二甲酸二戊酯(DPP)标准品

邻苯二甲酸二戊酯(DPP)标准品

货号:
SD9690

品牌:
Jinpan

邻苯二甲酸二戊酯(DPP)标准品

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产品简介
EC EINECS 205-017-9
MDL MFCD00041934
描述 密度:1.025?g/mL
别名 dipentyl phthalate;二戊基-1,2-苯二甲酸酯;邻酞酸二戊酯;邻酞酸二正戊酯;1,2-苯二甲酸二戊酯;DPP;
英文名称 Di-n-pentyl Phthalate
CAS 131-18-0
分子式 C18H26O4
分子量 306.4
储存条件 RT
单位
SMILES CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC
规格 100mg

苯甲酸阿格列汀

苯甲酸阿格列汀

货号:
IA3170

品牌:
Jinpan

苯甲酸阿格列汀

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产品简介
EC EINECS 691-730-4
MDL MFCD00064836
描述 是高活性DPP-4抑制剂。
别名 SYR-322
英文名称 Alogliptin Benzoate
CAS 850649-62-6
分子式 C18H21N5O2·C7H6O2
分子量 461.51
纯度 ≥98%
单位
生物活性 Alogliptin benzoate是一种有效的,选择性的DPP-4抑制剂。[1]
In Vivo We thus evaluated the chronic effects of the DPP-4 inhibitor alogliptin benzoate (formerly SYR-322) on metabolic control and beta-cell function in obese diabetic ob/ob mice. Alogliptin (0.002%, 0.01%, or 0.03%) was administered in the diet to ob/ob mice for 2 days to determine effects on plasma DPP-4 activity and active GLP-1 levels and for 4 weeks to determine chronic effects on metabolic control and beta-cell function. After 2 days, alogliptin dose-dependently inhibited DPP-4 activity by 28-82% and increased active GLP-1 by 3.2-6.4-fold. After 4 weeks, alogliptin dose-dependently decreased glycosylated hemoglobin by 0.4-0.9%, plasma glucose by 7-28% and plasma triglycerides by 24-51%, increased plasma insulin by 1.5-2.0-fold, and decreased plasma glucagon by 23-26%, with neutral effects on body weight and food consumption. Importantly, alogliptin also increased pancreatic insulin content up to 2.5-fold, and induced intense insulin staining of islets, suggestive of improved beta-cell function. In conclusion, chronic treatment with alogliptin improved glycemic control, decreased triglycerides, and improved beta-cell function in ob/ob mice, and may exhibit similar effects in patients with type 2 diabetes.[1]
SMILES O=C(C=C(N1C[C@H](N)CCC1)N(C2=O)CC3=C(C#N)C=CC=C3)N2C.O=C(O)C4=CC=CC=C4
靶点 Dipeptidyl Peptidase(DPP-4)
数据来源文献 [1]. Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32.
规格 5mg 10mg 25mg

是一种有效的,选择性的DPP-4抑制剂。