Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物,作为 CXCR4 的抑制剂,能够抑制 CXCR4 的表达,诱导凋亡,具有抗肿瘤活性。[1-3]
In Vitro
宝霍赛德I是CXCR4的抑制剂,并在12-25μM下调CXCR4表达。宝霍赛德I(0-25μM)以剂量依赖性方式抑制NF-κB活化,抑制CXCL12诱导宫颈癌细胞的侵袭。宝霍赛德我也抑制乳腺癌细胞的侵袭[1]。宝霍赛德I抑制A549细胞活力,24小时,11.5μM和9.6μM的48小时和72小时的IC50分别为25.1μM。宝霍赛德I((25μM)抑制A549细胞中的caspase级联,提高ROS水平并激活JNK和p38MAPK信号级联反应[2]。宝霍赛德I(3.125,6.25,12.5,25.0和50.0μg/ mL)显著且剂量依赖性阻断食管鳞状细胞癌Eca109细胞的生长,48小时IC50为4.8μg/ mL [3]。
[1]. Kim B, et al. Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. Biochemistry. 2014 Dec 9;53(48):7562-9. [2]. Song J, et al. Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. Chem Biol Interact. 2012 Jul 30;199(1):9-17. [3]. Wang L, et al. The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. Oncol Rep. 2011 Nov;26(5):1149-56.