苹果酸苏尼替尼 标准品
| EC | EINECS 638-825-9 |
| MDL | MFCD08282795 |
| 别名 | 苹果酸苏尼替尼;苹果酸舒尼替尼盐;sunitynib L-malate; |
| 英文名称 | Sunitinib Malate |
| CAS | 341031-54-7 |
| 分子式 | C22H27FN4O2·C4H6O5 |
| 分子量 | 532.56 |
| 储存条件 | -20℃ |
| 纯度 | HPLC≥97% |
| 外观（性状） | White to orange Powder |
| 单位 | 瓶 |
| SMILES | O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C2C=C(C=C3)F)=O)=C1C)C.O=C([C@H](CC(O)=O)O)O |
| 规格 | 50mg |
NADP-苹果酸脱氢酶(NADP-MDH)活性检测试剂盒,Micro NADP-Malate Dehydrogenase（NAD-MDH）Assay Kit,货号：BC1055-100管/96样
| 市场价： | ￥780.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 100管/96样 |
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产品详情
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苹果酸脱氢酶
| 有效期 | 2年 |
| 级别 | Ultra Pure Grade |
| 别名 | Malate dehydrogenase porcine heart；L-malate: NAD+oxidoreductase, mitochondrial malate dehydrogenase；MDH |
| 英文名称 | Malatedehydrogenase |
| CAS | 9001-64-3 |
| 分子量 | 70 kDa |
| 储存条件 | 2-8℃ |
| 酶活/效价 | 30.4KU/ML |
| 外观（性状） | 混浊液体 |
| 单位 | 支 |
| 规格 | 5KU |
苹果酸脱氢酶是细胞溶酶体中的一种氧化还原酶。
备注：产品信息可能会有优化升级。请以实际标签信息为准。
Pizotifen malate/BC-105 malate；苹果酸苯噻
| MDL | MFCD01700978 |
| EC | EINECS 225-970-4 |
| 别名 | BC-105malate |
| 英文名称 | Pizotifen malate/BC-105 malate |
| CAS | 5189-11-7 |
| 分子式 | C23H27NO5S |
| 分子量 | 429.53 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Pizotifen malate 是 5-HT2 受体的有效拮抗剂，并对5-HT1C 有高亲和力。[1-3] |
| In Vitro | Pizotifen是一种有效的5-HT2受体拮抗剂，对5-HT1C结合位点具有高亲和力[1]。 Pizotifen是一种抗过敏的5-HT2A受体拮抗剂，具有抑制5-羟色胺增强的ADP诱导的血小板聚集的能力[2]。 |
| In Vivo | 所有给药剂量的Pipethiadene和Pizotifen malate都显著降低了胎儿的体重;在0.6和1.2 mg / kg Pipethiadene之后，并且仅在中等剂量的Pizotifen苹果酸盐后，胎盘的重量显著减少。植入，活体，死胎，再吸收以及外部，骨骼和内脏异常的发生方式与对照组没有差异。处理小鼠的骨髓细胞中的染色体畸变数与阴性对照组没有显著差异。与对照组相比，微核试验显示微核的频率没有升高。在两种较高剂量的Pipethiadene和Pizotifen马来酸盐后，有丝分裂指数低于对照组[3]。 |
| SMILES | O=C(O)C(O)CC(O)=O.CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C2C=CS4 |
| 靶点 | Others |
| 动物实验 | 从妊娠第4天至第16天，以0.24,0.6和1.2mg / kg的剂量将小鼠[3]苹果酸马替替尼口服给予三组瑞士小鼠。对照组用蒸馏水处理。在妊娠第19天，处死小鼠并测定细胞遗传学检查和子宫内容物（活胎，异常和死胎的数量以及植入，再吸收的数量）。检查活体胎儿的外部，内脏和骨骼畸形[3]。 |
| 数据来源文献 | [1]. Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52. [2]. Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026. [3]. Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23(3-4):376-8 |
| 规格 | 100mg 200mg 500mg |
Pizotifen malate 是 5-HT2 受体的有效拮抗剂。
NAD-苹果酸脱氢酶(NAD-MDH)活性检测试剂盒,Micro NAD-Malate Dehydrogenase（NAD-MDH）Assay Kit,货号：BC1045-100管/96样
| 市场价： | ￥700.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 100管/96样 |
|
产品详情
说明书下载
参考文献
|
苹果酸舒尼替尼
| MDL | MFCD08282795 |
| EC | EINECS 638-825-9 |
| 别名 | 苹果酸苏尼替尼;苹果酸舒尼替尼盐;sunitynibL-malate |
| 英文名称 | Sunitinib Malate |
| CAS | 341031-54-7 |
| 分子式 | C22H27FN4O2·C4H6O5 |
| 分子量 | 532.56 |
| 纯度 | Purity≥99% |
| 单位 | 支 |
| 生物活性 | Sunitinib Malate (formerly also known as SU11248 Malate; trade nameSutent)) is a potent, orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor with potent anticancer activities. It inhibits VEGFR2 (Flk-1) and PDGFRβ with IC50s of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. It was approved by the FDA for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor on January 26, 2006. Sunitinib Malate is the malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of VEGFR2, PDGFRb, and c-kit, thereby inhibiting angiogenesis and cell proliferation. [1] |
| 激酶实验 | IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO4, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl2 so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl2 is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO4 and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.[2] |
| SMILES | O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C2C=C(C=C3)F)=O)=C1C)C.O=C([C@H](CC(O)=O)O)O |
| 靶点 | PDGFR |
| 数据来源文献 | [1]. J Med Chem. 2003;46(7):1116-9; Clin Cancer Res. 2003;9(1):327-37; Blood. 2003;101(9):3597-605. [2]. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119. |
| 规格 | 50mg 10mM*1mL in DMSO 100mg 200mg |
Sunitinib Malate是一种有效的酪氨酸激酶抑制剂， 抑制 VEGFR2 和 PDGFRβ。
Sodium D,L-Malate
| CAS | 63474-37-3 |
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 50mg |