Mincle 激动剂及相关产品推荐
Mincle是一个多功能的危险信号感知分子，可识别一系列配体，包括受损的细胞、真菌、酵母和结合分枝杆菌。Mincle的胞外配体包括真菌的α-mannose(甘露糖)、分枝杆菌的糖脂和来自结核分枝杆菌具有免疫刺激功能的TDM(trehalose-6’6’-dimycolate)组分。此外，Mincle还可通过识别其内源的DAMP来感知受损的细胞。SAP130(剪接体相关蛋白130)是已被发现的DAMP之一，它是一种由坏死细胞释放的可溶性因子。Mincle通过Syk激酶传递信号，透过CARD9来激活NF-κB。Syk还可引起胞内的钙动员和calcineurin-NFAT信号通路的活化。
相关产品推荐：
|
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
|
Mincle Agonists |
|||||
|
GlcC14C18 NEW |
Glucosyl-6-tetradecyloctadecanoate |
TLR2 -/ TLR4 – |
10 ng – 1 µg/ml |
2 mg |
tlrl-gcc |
|
HKMT |
Heat Killed Mycobacterium tuberculosis |
TLR2 +/ TRL4 – |
10 – 100 µg/ml |
10 mg 50 mg |
tlrl-hkmt-1 tlrl-hkmt-5 |
|
TDB |
Synthetic analog of the cord factor |
TLR2 -/ TLR4 – |
1 – 100 µg/ml |
2 mg |
tlrl-tdb |
|
TDB VacciGrade™ |
Preclinical grade TDB |
VacciGrade™ |
1 – 100 µg/mouse |
2 mg |
vac-tdb |
|
TDB-HS15 |
Formulated TDB |
TLR2 -/ TLR4 – |
0.3 – 100 µg/ml |
2 mg |
tlrl-stdb |
|
TDM NEW |
Trehalose-6,6-dimycolate; also known as cord factor |
TLR2 -/ TLR4 – |
300 ng-10 μg/ml |
2 mg |
tlrl-tdm |