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Tiopronin；硫普罗宁

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Tiopronin；硫普罗宁

货号：
IT2070

品牌：
Jinpan

Tiopronin；硫普罗宁

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产品简介
有效期 2年
MDL MFCD00004861
EC EINECS 217-778-4
InChIKey YTGJWQPHMWSCST-UHFFFAOYSA-N
InChI InChI=1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
PubChem CID 5483
别名 巯基丙酰甘氨酸；N-(2-巯基丙酰基)-甘氨酸
CAS 1953-02-2
分子式 C5H9NO3S
分子量 163.19
储存条件 2-8℃
纯度 ≥98%
外观（性状） Off-white Solid
单位 瓶
生物活性 Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1-2].
In Vitro In in vitro Von Hippel-Lindau protein binding assay, the inhibitory effect of Tiopronin (NMPG) on HPH-2 was attenuated by escalating dose of ascorbate but not 2-ketoglutarate, cofactors of the enzyme[2].
In Vivo Tiopronin (NMPG) alleviates colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuates expression of pro-inflammatory mediators in the inflamed colon. NMPG induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, leading to elevated secretion of vascular endothelial growth factor (VEGF), a target gene product of HIF-1 involved in ulcer healing of gastrointestinal mucosa. NMPG induces HIF-1α occurred by inhibiting HIF prolyl hydroxylase-2 (HPH-2), an enzyme that plays a major role in negatively regulating HIF-1α protein stability[2].
SMILES O=C(O)CNC(C(S)C)=O
靶点 Others
数据来源文献 [1]. Pu Zhang, et al. Detection of tiopronin in body fluids and pharmaceutical products using red-emissive DNA-stabilized silver nanoclusters as a fluorescent probe. Mikrochim Acta. 2019 Aug 8;186(9):609.
[2]. Soohwan Yum, et al. N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1008-13.
规格 100mg 200mg 500mg

是甘氨酸的巯基酰化类似物。