标签归档：西洛

西洛他唑

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西洛他唑

货号：
IC1880

品牌：
Jinpan

西洛他唑

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西洛他唑

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产品简介
MDL MFCD00866780
EC EINECS 689-122-9
InChIKey RRGUKTPIGVIEKM-UHFFFAOYSA-N
InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
PubChem CID 2754
别名 OPC 21; OPC 13013
英文名称 Cilostazol
CAS 73963-72-1
分子式 C20H27N5O2
分子量 369.46
纯度 ≥99%
单位 瓶
生物活性 Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM[1-2].
IC50 0.2 μM ( PDE 3A)[1]
In Vitro Cilostazol selectively inhibits cGMP-inhibited phosphodiesterase (PDE 3) and is a potent inhibitor of platelet aggregation induced by various agonists.Cilostazol inhibits stress-induced human platelet aggregation (SIPA) dose-dependently, with an IC50 of 15 μM for SIPA, and with a similar IC50 of 12.5 μM for ADP-induced platelet aggregation[2]. Cilostazol directly and effectively inhibits the activation of HSC but not of Kupffer cells[3].
In Vivo ilostazol (clinically used doses; p.o.; for 2 weeks) could alleviate CCl4 -induced hepatic fibrogenesis in vivo, presumably due to its direct effect to suppress HSC activation[3].
SMILES O=C1NC2=C(C=C(OCCCCC3=NN=NN3C4CCCCC4)C=C2)CC1
靶点 Phosphodiesterase (PDE)
数据来源文献 [1]. Schr?r K. The pharmacology of cilostazol. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9.

[2]. Minami N, et al. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Life Sci. 1997;61(25):PL 383-9.

[3]. Saito S, et al. Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis. Hepatol Res. 2013 Apr 19.
规格 10mg 50mg 100mg

是一种有效的选择性磷酸二酯酶3型抑制剂（PDE3）。它也是腺苷摄取抑制剂。

Cilostamide；西洛酰胺

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Cilostamide；西洛酰胺

货号：
IC3850

品牌：
Jinpan

Cilostamide；西洛酰胺

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产品简介
有效期 2年
InChIKey UIAYVIIHMORPSJ-UHFFFAOYSA-N
InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
PubChem CID 2753
别名 斯台酰胺；OPC-3689
CAS 68550-75-4
分子式 C20H26N2O3
分子量 342.43
储存条件 2-8℃
纯度 ≥98%
外观（性状） Off-white Solid
单位 瓶
SMILES O=C(N(C1CCCCC1)C)CCCOC2=CC3=C(NC(C=C3)=O)C=C2
靶点 Phosphodiesterase (PDE)
规格 5mg 10mg
是一种有效且高度选择性的III型磷酸二酯酶（PDE3）抑制剂