标签归档：雪松

雪松醇 标准品

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雪松醇 标准品

货号：
SC9130

品牌：
Jinpan

雪松醇 标准品

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产品简介
EC EINECS 201-035-6
MDL MFCD00062952
别名 柏木脑;
英文名称 Cedrol
CAS 77-53-2
分子式 C15H26O
分子量 222.37
储存条件 2-8℃
纯度 GC≥98%
外观（性状） Off-white Powder
单位 瓶
SMILES O[C@]1(C)CC[C@@]23[C@H](C)CC[C@@]2([H])C(C)(C)[C@@]1([H])C3
规格 20mg

Cedrol；雪松醇

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Cedrol；雪松醇

货号：
IC1580

品牌：
Jinpan

Cedrol；雪松醇

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Cedrol；雪松醇

暂无详情
产品简介
EC EINECS 201-035-6
MDL MFCD00062952
别名 柏木脑
英文名称 Cedrol
CAS 77-53-2
分子式 C15H26O
分子量 222.37
纯度 GC≥98%
单位 支
生物活性 Cedrol is bioactive sesquiterpenes found in cedar essential oil and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative, insecticidal, and antifungal activities. Cedrol was found to be potent competitive inhibitors of CYP2B6-mediated bupropion hydroxylase . [1-3]
In Vitro Cedrol is an anti-inflammatory constituent, anti-microbial ingredient and antibiosis agent[1]. Cedrol could accelerate fibroblast growth in a dose-dependent manner and increase the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and Akt are also markedly increased by the treatment of cedrol, indicating that cedrol stimulates ECM production[3]. Cedrol is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities[2].
In Vivo Cedrol can promote hair reproduction. It promotes hair regeneration and shortens the telogen phase of hair follicles after alopecia occurs. Cedrol may possess a latent ability of preventing damage to initiatory hair follicle and restoring the morphological characteristics of follicles after they have been damaged by chemotherapy. Cedrol is a PAF (platelet-activating factor) antagonist that can reduce or inhibit platelet aggregation, skin inflammation, and vascular disorders[1].
SMILES O[C@]1(C)CC[C@@]23[C@H](C)CC[C@@]2([H])C(C)(C)[C@@]1([H])C3
靶点 Cytochrome P450
数据来源文献 [1] Chen SS, et al. Environ Toxicol Pharmacol. 2016, 46:270-276.
[2] Jeong HU, et al. J Toxicol Environ Health A. 2014, 77(22-24):1522-32.
[3] Jin MH, et al. Ann Dermatol. 2012, 24(1):16-21.
规格 20mg 50mg 100mg

Cedrol 是一种生物活性倍半萜，一种有效的细胞色素 P-450(CYP) 酶竞争性抑制剂。