标签归档：asp

ASP2905

发表于由

ASP2905CAS号： 792184-90-8分子式： C20H17FN8分子量： 388.4描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)

产品描述
描述
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities
纯度
98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:27.5 mg/mL (70.8 mM)
生物活性
In vitro(体外研究)
ASP2905 (0.1 M, 1 M) decreased the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons.?In mice, ASP2905 reversed the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine (minimum effective dose of ASP2905: 0.0625mg/kg, po).?ASP2905 ameliorated the cognitive deficits of aged rats in step-through passive avoidance (0.0313 and 0.0625mg/kg, po) and Morris water-maze tasks (0.01mg/kg, po) and effectively penetrated the brain.?The mean plasma and brain concentrations of ASP2905 reached their maxima (Cmax = 0.399ng/ml and 1.77ng/g, respectively) 1h after a single oral administration and then decreased (t1/2 = 1.5-1.6h) (brain plasma ratio = 2.7-4.9).?ASP2905 is a selective, orally administered inhibitor of KCNH3, which can enhance cognitive performance[1].
In vivo(体内研究)
ASP2905 on channel activity in vitro and its neuropharmacological properties in young and aged rats as well as in mice.?ASP2905 potently inhibited potassium currents in CHO cells expressing KCNH3 (IC50 = 9.0nM).?In contrast, ASP2905 ( 10μM) minimally bound with low affinities to 55 transmembrane proteins.[1]

Rabbit anti-Cleaved PARP(Asp214) Polyclonal Antibody

发表于由

Rabbit anti-Cleaved PARP(Asp214) Polyclonal Antibody别名宿主特异性反应种属应用分子量类型同种型储存/保存方法

概述
别名
Cleaved PARP (Asp214)抗体
宿主
Rabbit
特异性
This Cleaved PARP (Asp214) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-225 amino acids from the human region of human Cleaved PARP (Asp214).
反应种属
Human
应用
WB
分子量
Predicted molecular weight: 113kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
性能
类型
Polyclonal Antibody
同种型
Rabbit Ig
储存/保存方法
Maintain refrigerated at 2-8°C for up to 2 weeks. For long time storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Ac-Asp-Glu-Val-Asp-7-氨基-4-甲基香豆素

发表于由

Ac-Asp-Glu-Val-Asp-7-氨基-4-甲基香豆素CAS号： 169332-61-0分子式： C30H37N5O13分子量： 675.6描述序列纯度储存/保存方法别名外观可溶性/溶解性

产品描述
描述
Ac-DEVD-AMC is a fluorogenic substrate that can be cleaved specifically by caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
序列
Ac-DEVD-AMC
纯度
≥95%
储存/保存方法
Store at -20℃，1 year.
基本信息
别名
AC-DEVD-AMC
外观
white powder
可溶性/溶解性
DMSO

分子结构图

Ac-Asp-Glu-Val-Asp-7-氨基-4-甲基香豆素

ASP-3026

发表于由

ASP-3026

货号：
IA3460

品牌：
Jinpan

ASP-3026

暂无详情
产品简介
有效期 2年
描述 是一种高活性ALK抑制剂。
MDL MFCD00064808
EC EINECS 200-258-5
英文名称 ASP-3026
CAS 1097917-15-1
分子式 C29H40N8O3S
分子量 580.75
储存条件 -20℃
纯度 ≥98%
外观（性状） Solid
单位 瓶
生物活性 ASP3026 是一种新型选择性ALK 抑制剂，其IC50 为3.5 nM.[1]
IC50 ALK: 3.5 nM[1]
In Vitro ASP3026在酪氨酸激酶中比PF02341066显示更强的选择性抑制ALK活性。ASP3026抑制人非小细胞肺癌肿瘤细胞系NCI-H2228中内源性表达EML4-ALK突变体3的生长，IC 50为64.8 nM。[1]
In Vivo 给皮下NCI-H2228肿瘤异种移植物小鼠为每天口服ASP3026两次至14天，诱导了剂量依赖性的抗肿瘤效应,在1毫克/千克开始作用，在10，30和100毫克/千克时有较强的抑制作用。 [1]
SMILES COC(C=C(N1CCC(N2CCN(C)CC2)CC1)C=C3)=C3NC4=NC=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=N4
靶点 ALK
数据来源文献 [1] Sadao Kuromitsu, et al. AACR 102nd Annual Meeting, 2011.
规格 5mg 10mg

Rabbit anti-Cleaved PARP-1(Asp214) Monoclonal Antibody(JRMR-243)

发表于由

Rabbit anti-Cleaved PARP-1(Asp214) Monoclonal Antibody(JRMR-243)别名宿主反应种属应用分子量纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
Cleaved PARP-1(Asp214) 抗体;ADPRT1; PPOL
宿主
Rabbit
反应种属
Human, Mouse
应用
WB:1:2000; IHC-P:1:200-1:1000; ICC/IF:1:50;
分子量
Predicted molecular weight: 25kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-243
同种型
IgG
储存/保存方法
储存温度：-20℃，避免反复冻融
靶标
背景说明
聚-ADP-核糖基转移酶介导蛋白质的聚-ADP-核糖基化并在DNA修复中起关键作用。 主要介导目标蛋白的谷氨酸和天冬氨酸ADP-核糖基化：NAD +的ADP-D-核糖基转移至谷氨酸和天冬氨酸残基的受体羧基，另外ADP-核糖基转移至末端的2′-位置 腺苷部分，形成平均链长为20-30个单位的聚合物。
细胞定位
细胞核
UniProt
P09874

阿莫奈韦

发表于由

阿莫奈韦

货号：
IA4260

品牌：
Jinpan

阿莫奈韦

暂无详情
产品简介
别名 ASP-2151
英文名称 Amenamevir
CAS 841301-32-4
分子式 C24H26N4O5S
分子量 482.55
储存条件 -20度
纯度 ≥98%
单位 瓶
生物活性 Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.[1]
In Vitro ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2].
In Vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2].
SMILES O=C(C(CC1)CCS1(=O)=O)N(C2=C(C)C=CC=C2C)CC(NC3=CC=C(C4=NOC=N4)C=C3)=O
靶点 DNA/RNA Synthesis inhibitor
细胞实验 Animal Models: HSV-1-infected mice; Dosages: 1, 3, 10, 30, or 100 mg/kg/day; Administration: oral[2]
数据来源文献 [1] Kawashima M, et al. J Dermatol. 2017, 44(11):1219-1227.
[2] Katsumata K, et al. Antimicrob Agents Chemother. 2013, 57(3):1339-46.
规格 5mg

是一种HSV（单纯疱疹病毒）解旋酶-引发酶抑制剂，对HSV具有强抗病毒活性

4-Di-1-ASP线粒体荧光探针 货号: D4013 规格: 200 mg

发表于由

4-Di-1-ASP线粒体荧光探针

产品货号: D4013

产品规格: 200 mg

目录价（元）:250

推荐仪器：荧光显微镜

大包装询价


产品概述：
产品参数
外观：可溶于 DMSO 或 DMF 的橘色固体
Ex/Em：474/606 nm (MeOH)
CAS 号：68971-03-9
分子式：C16H19IN2
分子量：366.2

分子结构图：

4-Di-1-ASP线粒体荧光探针 货号: D4013 规格: 200 mg

储存条件
-20℃ 避光保存，有效期见外包装。

产品介绍
4-Di-1-ASP 是苯乙烯基染料，用于染色活细胞线粒体。它也被用于染色神经胶质瘤细胞、活体大脑组织等。

注意事项
1. 荧光染料均存在淬灭问题，请尽量注意避光，以减缓荧光淬灭。
2. 为了您的安全和健康，请穿实验服并戴一次性手套操作。
说明书：

4-Di-1-ASP线粒体荧光探针 货号: D4013 规格: 200 mg UE-D4013    
MSDS：
MSDS D4013 4-Di-1-ASP

Naquotinib

发表于由

Naquotinib

货号：
IN0930

品牌：
Jinpan

Naquotinib

暂无详情
产品简介
别名 ASP8273
CAS 1448232-80-1
分子式 C30H42N8O3
分子量 562.71
储存条件 -20℃
纯度 ≥98%
单位 瓶
生物活性 Naquotinib (ASP8273)是一种具有口服活性的、不可逆的、对突变体具有选择性的epidermal growth factor receptor (EGFR)抑制剂，具有潜在的抗肿瘤活性。[1-2]
In Vitro ASP8273是一种不可逆的TKI小分子抑制剂，抑制EGFR突变体包括T97M的激酶活性，而对野生型EGFR的活性有限。在体外酶活性和细胞实验中，ASP8273与EGFR突变体(L858R/T790M)通过半胱氨酸残基共价结合，长效抑制EGFR的磷酸化24小时。在具有上述EGFR突变的NSCLC细胞系中，ASP8273对EGFR突变体的IC50值在8-33 nM 范围间，比对WT EGFR更有效（对WT EGFR的IC50为230 nM）。ASP8273还能通过ERK和Akt抑制信号通路。在对耐其他EGFR TKIs如AZD9291和CO-1686的突变EGFR细胞系张，ASP8273具有活性[1-2]。
In Vivo 在小鼠肿瘤异种移植研究中，给NCI-H1975 (L858R/T790M), HCC827 (del ex19) and PC-9 (del ex19)异种移植小鼠予以重复的口服给药，ASP8273能以剂量依赖方式诱导肿瘤消退。给药方案并不影响ASP8273的效力。在HCC827和NCI-H1975模型中，10, 30, 100mg/kg的ASP8273可诱导肿瘤消退，而不影响其体重。在NSCLC患者肿瘤源性的异种移植模型（抑制了表达T790M/L858R的LU1868）中，10 mg/kg以上的ASP8273将产生肿瘤生长抑制；另一方面，10 和30mg/kg ASP8273在A431异种移植的模型中没有显著的肿瘤生长抑制作用[1-2]。
SMILES O=C(C1=NC(CC)=C(O[C@H]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N
靶点 EGFR
动物实验 ASP8273 selectively inhibited phosphorylation of EGFR and its down-stream signal pathway, ERK and Akt from 10nM in HCC827 and NCI-H1975 while inhibitory effects were only detected at 1000nM in A431.In NCI-H1650 (del ex19), ASP8273 inhibited cell growth with an IC50 value of 70nM while other EGFR-TKIs were only partially effective. ERK and Akt phosphorylation were diminished after ASP8273 treatment at 1000nM, however, other EGFR-TKIs only partially reduced the phosphorylation levels of these proteins. ASP8273 potently enhanced the caspase activity in NCI-H1650 after 24h treatment, which is concordant with signal and cell growth inhibitory effect.[2]
细胞实验 In HCC827 and NCI-H1975 xenograft models, ASP8273 induced tumor regression at 10, 30 and 100mg/kg without affecting body weight. ASP8273 also produced tumor growth inhibition from 10mg/kg in the NSCLC patient derived tumor xenograft, LU1868 which express T790M/L858R.[2]
数据来源文献 [1] Sakagami H, et al. Cancer Res. 2014, 74(19 Supplement):1728.
[2] Konagai S, et al. Cancer Res. 2015, 75(15 Supplement):2586.
规格 5mg

Naquotinib是一种不可逆的、对突变体具有选择性的epidermal growth factor receptor (EGFR)抑制剂