CRT0066101 Dihydrochloride
| MDL | MFCD30182249 |
| 别名 | CS-2578 |
| 英文名称 | CRT0066101 Dihydrochloride |
| CAS | 1883545-60-5 |
| 分子式 | C18H24Cl2N6O |
| 分子量 | 411.33 |
| 储存条件 | -20°C |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| SMILES | N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1.Cl.Cl |
| 靶点 | PKD |
| 规格 | 5mg 10mg |
CRT0273750CAS号： 1979939-16-6分子式： C25H22ClF3N4O2分子量： 502.92描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
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| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:200 mg/ml(397.68 mM)
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| 生物活性 | |
| 靶点 |
ATX:0.014 μM
|
| In vitro(体外研究) |
CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM[1]. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM)[1].
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| In vivo(体内研究) |
CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase[1].CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg[1].
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