标签归档：ascorbate

抗坏血酸钠

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抗坏血酸钠

货号：
IS2410

品牌：
Jinpan

抗坏血酸钠

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产品简介
有效期 2年
MDL MFCD00082340
EC EINECS 205-126-1
别名 维生素C钠
英文名称 Sodium Ascorbate
CAS 134-03-2
分子式 C6H7NaO6
分子量 198.11
储存条件 2-8℃
纯度 ≥98%
外观（性状） White to yellow Powder
单位 瓶
生物活性 L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1-3].
In Vitro The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].
In Vivo Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5].
SMILES C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
靶点 Cav3.2 channels
动物实验 A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.[3]
数据来源文献 [1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
[2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
[3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.
[4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.
[5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.
[6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
规格 100mg 200mg 500mg

是一种电子供体和内源性抗氧化剂，选择性抑制 Cav3.2 channels。