CL-82198 CAS号： 307002-71-7分子式： C17H22N2O3分子量： 302.37描述纯度储存/保存方法外观可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 外观 |
white to off-white powder
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| 可溶性/溶解性 |
DMSO ：60 mg/mL (198.43 mM)
Ethanol ：60 mg/mL (198.43 mM) |
| 生物活性 | |
| In vitro(体外研究) |
L-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration.
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells. |
| In vivo(体内研究) |
CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression.
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分子结构图
