FTI-277盐酸盐
| 有效期 | 2年 |
| MDL | MFCD06411717 |
| EC | EINECS 604-604-1 |
| 英文名称 | FTI-277 Hydrochloride |
| CAS | 180977-34-8 |
| 分子式 | C22H29N3O3S2·HCl |
| 分子量 | 484.07 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white Powder |
| 单位 | 瓶 |
| SMILES | CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl |
| 靶点 | Farnesyl Transferase |
| 规格 | 2mg 5mg |
FTI-2628分子式： C31H34N4O3S分子量： 542.69描述应用纯度储存/保存方法形态密度沸点可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
FTI-2628 is a cell-permeable benzyl ester prodrug form of FTI-2148 that preferentially inhibits protein farnesyltransferase activity over protein geranylgeranyltransferase-I. The compound displays anti-malarial properties. FTI-2628 potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells and inhibits the growth of P. falciparumi in red blood cells.
|
| 应用 |
A cell-permeable benzyl ester from of FTI-2148
|
| 纯度 |
≥95%
|
| 储存/保存方法 |
Store at -20° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 密度 |
1.216 g/cm3
|
| 沸点 |
768.19° C at 760 mmHg (Predicted)
|
| 可溶性/溶解性 |
Soluble in DMSO or Methanol
|
| PubChem CID |
16760438
|
FTI-276 trifluoroacetate saltCAS号： 170006-72-1(non-salt)分子式： C21H27N3O3S2•C2HF3O2分子量： 547.61描述应用储存/保存方法形态别名可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
FTI-276 trifluoroacetate salt is a highly potent RasCAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. This compound inhibits farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM. RasCAAX as an anti-cancer agent.
|
| 应用 |
A highly potent RasCAAX peptidomimetic
|
| 储存/保存方法 |
Desiccate at -20° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
|
| 可溶性/溶解性 |
Soluble in Water: >5 mg/mL
|
| MDL |
MFCD06409253
|
| PubChem CID |
395753
|
FTI 277CAS号： 170006-73-2分子式： C22H29N3O3S2·C2HF3O2分子量： 561.64描述纯度储存/保存方法别名可溶性/溶解性靶点
| 产品描述 | |
| 描述 |
FTI 277 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 nM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
FTI-277,FTI277
|
| 可溶性/溶解性 |
Soluble in Water: ≥2 mg/mL
|
| 生物活性 | |
| 靶点 |
Farnesyl Transferase
|
分子结构图
FTI 277 hydrochlorideCAS号： 180977-34-8分子式： C22H30ClN3O3S2分子量： 484.07描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
FTI 277 hydrochloride is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
FTI 277 HCl；FTI 277
|
| 外观 |
amorphous semi-solid
|
| 可溶性/溶解性 |
DMSO : 89 mg/mL (183.9 mM)
Ethanol : 12 mg/mL (24.8 mM) Water : 14 mg/mL (28.9 mM) |
| 生物活性 | |
| 靶点 |
FTase
|
| In vitro(体外研究) |
FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm, and blocks constitutive MAPK activation in H-RasF cells. FTI-277 causes increased apoptosis after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. In SH-SY5Y cells, FTI-277 diminishes the toxic effects of methamphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation.
|
| In vivo(体内研究) |
In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d i.p.) effectively clears HDV viremia.
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| 参考文献 | |
| 参考文献 |
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分子结构图
