标签归档：sulfate

硫酸链霉素

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硫酸链霉素

货号：
IS0360

品牌：
Jinpan

硫酸链霉素

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产品简介
MDL MFCD00037023
EC EINECS 223-286-0
别名 链霉素硫酸盐
英文名称 Streptomycin Sulfate
CAS 3810-74-0
分子式 2(C21H39N7O12)·3(H2SO4)
分子量 1457.38
纯度 ≥98%
单位 瓶
生物活性 Streptomycin sulfate 是一种氨基糖苷类抗生素，能够抑制蛋白质的合成。[1-2]
In Vitro 随着生长培养基中CV浓度的增加，菌株RB1显示出对链霉素的增强的易感性。随着生长培养基中CV浓度的增加，细胞色素aa3水平和链霉素敏感性均增加。细胞色素aa3是枯草芽孢杆菌积累链霉素所必需的[1]。链霉素影响tRNA选择。链霉素抗性突变通常映射到蛋白质S12，并且大多数这些变体在tRNA选择过程中表现出增加的区分[2]。
SMILES O[C@@]1(C=O)[C@H]([C@@H](O[C@H]1C)O[C@]([C@@H]([C@@H](O)[C@@H]2NC(N)=N)O)([H])[C@H]([C@@H]2O)NC(N)=N)O[C@@](O[C@@H](CO)[C@H](O)[C@H]3O)([H])[C@H]3NC.[1.5H2SO4]
靶点 Bacterial
数据来源文献 [1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12.

[2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76.
规格 50mg 10mM*1mL (in Water) 100mg

Streptomycin sulfate 是一种氨基糖苷类抗生素，能够抑制蛋白质的合成。

Chondroitin sulfate；硫酸软骨素

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Chondroitin sulfate；硫酸软骨素

货号：
IC1110

品牌：
Jinpan

Chondroitin sulfate；硫酸软骨素

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产品简介
EC EINECS 232-696-9
MDL MFCD00146419
InChIKey KXKPYJOVDUMHGS-OSRGNVMNSA-N
InChI InChI=1S/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/s1
PubChem CID 24766
别名 鲨鱼软骨素;Cholyltaurine
英文名称 Chondroitin sulfate
CAS 9007-28-7
分子式 (C14H21NO14S)n
纯度 HPLC≥98%
单位 瓶
生物活性 Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.[1-5]
In Vitro Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS, MMPs[4].Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, e.g., bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]. A large range of chondroitin sulfate concentrations has been used (e.g. 12.5 to 2000 mg/mL, but generally less than200 mg/mL) in in vitro studies. Chondroitin sulfate (200 mg/mL) decreases the chondrocyte susceptibility to single nucleotide polymorphism-induced apoptosis[3]. Chondroitin sulfate is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine. Several pathogens including parasites, bacteria, and viruses have been shown to utilize cell surface chondroitin sulfate chains to attach to and infect host cells[1].
In Vivo Chondroitin sulfate is mostly administered orally at doses ranging from 800 to 1200mg/day. Chondroitin sulfate is rapidly absorbed by the gastrointestinal tract. The absorbed chondroitin sulfate reaches the blood compartment as 10% chondroitin sulfate and 90% depolymerized low-molecular-weight derivatives[5].The high content of chondroitin sulfate in the aggrecan plays a major part in allowing cartilage to resist tensile stresses during various loading conditions by providing this tissue with resistance and elasticity. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis[3].
SMILES O=S(O)=O.O=S(O)=O.OC([C@@H]1[C@@H](OC)[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](NC(C)=O)[C@H](OC)O[C@H](CO[R])[C@@H]2O[R])O1)=O.[R].[R].[=].[=].[R2=].[R1=].[n].[or]
靶点 NO Synthase
细胞实验 Chondrocytes are cultured into six-well culture plates. 12 hours after plating, the culture medium is replaced with 2.0 mL of fresh medium containing LPS at a concentration of 50 mg/mL. 4 hours later, HA, Chondroitin sulfate, HS, keratan sulphate and DS are added separately to each of the wells at concentrations of 0.5 and 1.0 mg/mL. The number of viable chondrocytes is then quantified by trypan blue dye exclusion test from several randomly chosen areas of each well[4].
数据来源文献 [1]. Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct;1830(10):4719-33.

[2]. Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6;20(3):4277-89.

[3]. Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40.

[4]. Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92.

[5]. Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48.
规格 100mg 10mM*1mL in Water 500mg

是共价连接在蛋白质上形成蛋白聚糖的一类糖胺聚糖。硫酸软骨素广泛分布于动物组织的细胞外基质和细胞表面，糖链由交替的葡萄糖醛酸和N-乙酰半乳糖胺聚合而成，通过一个似糖链接区连接到核心蛋白的丝氨酸残基上。

Paromomycin (sulfate) 硫酸巴龙霉素

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Paromomycin (sulfate) 硫酸巴龙霉素

货号：
IP0080

品牌：
Jinpan

Paromomycin (sulfate) 硫酸巴龙霉素

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产品简介
MDL MFCD00079278
EC EINECS 215-031-7
别名 巴龙霉素硫酸盐; Paromomycin sulfate salt
CAS 1263-89-4
分子式 C23H47N5O18S
分子量 713.71
纯度 HPLC≥94%
单位 瓶
SMILES N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O
靶点 Parasite
规格 50mg 10mM*1mL in Water 100mg

为氨基糖甙类广谱抗生素，对革兰氏阴性杆菌、抗酸杆菌均有良好抑菌活性。

硫酸氨基葡萄糖 标准品

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硫酸氨基葡萄糖 标准品

货号：
SG8500

品牌：
Jinpan

硫酸氨基葡萄糖 标准品

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产品简介
EC EINECS 249-379-6
MDL MFCD00080790
别名 D-Glucosamine Sulfate Salt;
英文名称 Glucosamine sulfate
CAS 29031-19-4
分子式 C6H15NO9S
分子量 277.25
储存条件 2-8℃
纯度 HPLC≥98%
SMILES O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.O=S(O)(O)=O.[x]
规格 20mg

Phenelzine sulfate；苯基乙肼硫酸盐

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Phenelzine sulfate；苯基乙肼硫酸盐

货号：
IP1230

品牌：
Jinpan

Phenelzine sulfate；苯基乙肼硫酸盐

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产品简介
MDL MFCD00050687
EC EINECS 205-856-0
InChIKey RXBKMJIPNDOHFR-UHFFFAOYSA-N
InChI InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
PubChem CID 61100
别名 硫酸苯乙肼;2-phenylethylhydrazine,sulfuricacid
英文名称 Phenelzine sulfate
CAS 156-51-4
分子式 C8H14N2O4S
分子量 234.27
纯度 ≥98%
单位 支
SMILES NNCCC1=CC=CC=C1.O=S(O)(O)=O
靶点 MAO(Monoamine Oxidase)
规格 50mg 100mg 500mg
Phenelzine硫酸盐是一种非选择性和不可逆的单胺氧化酶抑制剂 (MAOI)， 用于抗抑郁药和抗焦虑药方向的而研究。