Tirasemtiv
货号：
IT2730
品牌：
Jinpan
暂无详情
产品简介
| 有效期 | 2年 |
| 描述 | 是一种新型的快速骨骼肌钙蛋白小分子激活剂。 |
| 别名 | CK-2017357 |
| CAS | 1005491-05-3 |
| 分子式 | C12H14N4O |
| 分子量 | 230.27 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | Solid |
| 单位 | 瓶 |
| 生物活性 | Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. [1] |
| In Vivo | A single dose of tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1 G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in tirasemtiv-treated female B6SJL-SOD1 G93A mice. [1] |
| SMILES | O=C1N(C(CC)CC)C2=NC(C#C)=CN=C2N1 |
| 靶点 | Others |
| 数据来源文献 | [1] Darren T Hwee, et al. PLoS One. 2014 May 7;9(5):e96921. |
| 规格 | 1mg 5mg 10mg |
