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Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. [1]
In Vivo
A single dose of tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1 G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in tirasemtiv-treated female B6SJL-SOD1 G93A mice. [1]
SMILES
O=C1N(C(CC)CC)C2=NC(C#C)=CN=C2N1
靶点
Others
数据来源文献
[1] Darren T Hwee, et al. PLoS One. 2014 May 7;9(5):e96921.