4-Biphenylacetic acid (BPAA) is a prostaglandin-synthesis inhibitor. [1]
In Vitro
In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea. It is suggested that BPAA may be useful for the therapy of ocular inflammatory disease.[1]
In Vivo
Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis.[1]4-Biphenylacetic acid (BPAA） markedly inhibits the ocular effects of both chemically and mechanically induced trauma[1].
SMILES
O=C(O)CC1=CC=C(C2=CC=CC=C2)C=C1
靶点
Others
数据来源文献
[1] Tolman EL, et al. Invest Ophthalmol. 1976, 15(12):1005-8.
BIOLOGICAL INDUSTRIES 05-010-1A “DCCM-1 without L-Glutamine 哺乳动物细胞悬浮培养无血清培养基” 500ml 4℃ BI公司 05-015-1A “DCCM-2 without L-Glutamine 哺乳动物细胞悬浮培养无血清培养基” 500ml 4℃ BI公司 05-040-1A “Low Protein Media BSA-Free (LPM), without L-Glutamine 哺乳动物细胞悬浮培养无血清培养基” 500ml 4℃
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Phenol Red 500ml AMB BI公司 02-020-1A Dulbecco's Phosphate Buffered Saline (DPBS) 500ml 4℃ BI公司 02-020-1B Dulbecco's Phosphate Buffered Saline (DPBS) 100ml 4℃ BI公司 02-023-1A Dulbecco's Phosphate Buffered Saline (DPBS), without Calcium and Magnesium 500ml AMB BI公司 02-023-1B Dulbecco's Phosphate Buffered Saline (DPBS), without Calcium and Magnesium 100ml AMB BioInd公司 02-023-5A Dulbecco's Phosphate Buffered Saline (DPBS), 10X Conc., without Calcium and Magnesium 500ml AMB BioInd公司 02-045-1A Alsever's Solution 500ml AMB BIOLOGICAL INDUSTRIES 02-045-1B Alsever's Solution 100ml AMB BIOLOGICAL INDUSTRIES 03-010-1B “Bovine Albumin Solution (10%), Fraction V in saline 牛白蛋白（10%）” 100ml -20℃ BIOLOGICAL INDUSTRIES 03-015-1B Ethylenediaminetetraacetic Acid (EDTA) Disodium Salt Solution, 0.05% in DPBS 100ml AMB BIOLOGICAL INDUSTRIES 03-020-1A “L-Glutamine Solution, 29.2mg/ml in Saline (200 millimole/liter) 谷氨酰胺溶液” 500ml -20℃ BIOLOGICAL INDUSTRIES 03-020-1B “L-Glutamine Solution, 29.2mg/ml in Saline 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◆实验结果使用什么仪器观察？ 实验结果可以通过流式细胞仪和荧光显微镜进行观察，但更推荐使用流式细胞仪。因为正常的细胞和凋亡的细胞膜上都有磷脂酰丝氨酸（PS），只是凋亡细胞膜外更多，可以结合更多的Annexin V，流式细胞仪更灵敏，可以区分出微小差异，将正常细胞与凋亡细胞分成不同的两群，但如果用荧光显微镜，可能观察不到这一差别，尤其是贴壁细胞。若要在成像测定中检测细胞凋亡，推荐使用SuperView™ 488 Caspase-3 Assay Kit for Live Cells。
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UE-A6079S/A6079M/A6079L 
