糖精钠二水 标准品
| EC | EINECS 204-886-1 |
| MDL | MFCD00151213 |
| 别名 | o-Benzoic Sulfimide Sodium Salt Dihydrate;邻苯甲酰磺酰亚胺钠盐二水合物;1,1-二氧代-1,2-苯并异噻唑-3(2H)-酮钠盐;邻苯甲酰磺酰亚胺钠(二水); |
| 英文名称 | Saccharin sodium dihydrate |
| CAS | 6155-57-3 |
| 分子式 | C7H4NNaO3S·2H2O |
| 分子量 | 241.20 |
| 储存条件 | RT |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| SMILES | C1=CC=C2C(=C1)C(=O)NS2(=O)=O.O.O.[Na] |
| 规格 | 100mg |
盐酸阿米洛利二水合物
| EC | EINECS 620-474-8 |
| 别名 | MK-870hydrochloridedihydrate |
| 英文名称 | Amiloride hydrochloride Dihydrate |
| CAS | 17440-83-4 |
| 分子式 | C6H8ClN7O.HCl.2H2O |
| 分子量 | 302.12 |
| 储存条件 | -20℃ |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.[1-8] |
| In Vitro | Amiloride也诱导P13K（磷脂酰肌醇3-激酶），PDK-1（磷酸肌醇依赖性激酶-1），PTEN（磷酸酶和张力蛋白同系物10号染色体上删除）和PP1阿尔法磷酸激酶的去磷酸化。Amiloride通过与ATP竞争抑制磷酸激酶和磷酸酶的磷酸化。Amiloride，这本身导致很少或没有细胞毒性，增强TRAIL诱导的细胞凋亡。[1] Amiloride排除了碱化，并联抑制细胞增生。Amiloride直接抑制EGF受体的自磷酸化。[2] Amiloride显著增强恢复到39％，88％和78％，分别为+ dF/dt和-dF/dt。[3] Amiloride阻断phorbol酯诱导的HL-60细胞粘附（粘附是分化状态的指示），但dimethylamiloride（以及ethylisopropylamiloride，另一种非常有效的amiloride类似物）没有。[4] 在兔完整近端小管中，在不同浓度的细胞外钠的存在下，Amiloride抑制ouabain敏感的耗氧量（QO2）。[5] |
| In Vivo | Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[6]. |
| 货期 | 1-2天 |
| SMILES | O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O |
| 靶点 | Sodium Channel |
| 动物实验 | The experiments are performed on male and female Sprague-Dawley rats that have been maintained in a heat controlled room maintained at 23° C with a 12h/12h light-dark schedule. A total of 116 adult rats are injected i.p. with Amiloride hydrochloride dihydrate (0.1, 0.5, and 2.0 mg/kg). After 15, 30, 45, or 120 min post-injection, the rats are anesthetized with 8% chloral hydrate, the chest is opened, and blood samples are obtained by cardiac puncture. The blood is centrifuged at 5000 RPM for 5 min, and the plasma (1.5 mL) separated and stored at -80° C[6]. |
| 数据来源文献 | [1] Kim KM, et al. Oncogene,?005, 24(3), 355-366. [2] Koivusalo M, et al. J Cell Biol,?010, 188(4), 547-563. [3] Karmazyn M, et al. Am J Physiol,?988, 255(3 Pt 2), H608-615. [4] Besterman JM, et al. J Biol Chem,?985, 260(2), 1155-1159. [5] Soltoff SP, et al. Science,?983, 220(4600), 957-958. [6]. Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [7]. Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. [8]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. |
| 规格 | 100mg 500mg |
是上皮钠通道 (ENaC) 和尿激酶型纤溶酶原激活物受体 (uTPA) 的抑制剂。也是 polycystin-2 (PC2; TRPP2) 通道阻断剂。
使用本产品的应用案例（仅供参考）
In Vitro
Cell（HepG2）, 200 µg/mL, 1 h, 37°C
For initial study of cellular internalization, NPs-EPI was incubated with tumor spheroids at an EPI concentration of 8 µg/mL for 4 h. The tumor spheroids were grown as our previous reported procedure. Briefly, HepG2 cells were seeded in 96-well plates at a density of 8×103 per well precoated with 50 µL of 1% low melting point agarose. Cells were cultured to obtain multicellular spheroids (400–500 μm in diameter) for subsequent studies. After incubation with NPs-EPI, tumor spheroids were rinsed three times with cold PBS and processed for image analysis by TEM.
To investigate the internalization pathways of NPs-EPI, HepG2 cells were seeded into 6-well plates with 2×105 cells per well and incubated for 24 hours. The cells were then pre-treated with different endocytic inhibitors (chlorpromazine hydrochloride 20 µg/mL, amiloride hydrochloride 200 µg/mL) at 37°C for 1 hour. Subsequently, NPs-EPI (EPI 8 µg/mL) were added and incubated at 37°C for 2 hours. Finally, the cells were washed three times with cold PBS and harvested for flow cytometry to determine the fluorescence intensity of EPI (Ex=488, Em=588). Cells pre-treated with PBS at 37°C served as the positive control group. Internalization assays were also performed in the absence of endocytic inhibitors at 4°C when indicated.
来源文献：Chen E, Han S, Song B, Xu L, Yuan H, Liang M, Sun Y. Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect. Int J Nanomedicine. 2020 Aug 24;15:6311-6324. doi: 10.2147/IJN.S257164. PMID: 32922003; PMCID: PMC7458542.
Sodium 4-aminosalicylate dihydrate 对氨基水杨酸钠
货号：BS220-25g
规格：25g
品牌：Jinpan
对氨基水杨酸钠
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产品编号 |
产品名称 |
规格 |
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BS220-25g |
对氨基水杨酸钠 |
25g |
产品简介：
对氨基水杨酸钠能通过对叶酸合成的竞争性抑制作用而抑制结核分枝杆菌的生长繁殖。无臭，味甜带咸，溶于水，极微溶于丙酮，几乎不溶于乙醚、氯仿和苯。露置空气中颜色逐渐变暗。
别名：4-氨基-2-羟基苯甲酸钠盐 二水合物 ；4-氨基水杨酸钠盐 二水合物；Sodium 4-aminosalicylate dihydrate;4-Aminosalicylic acid sodium salt dihydrate；4-Amino-2-hydroxybenzoic Acid Sodium Salt Dihydrate
英文名称：Sodium 4-aminosalicylate dihydrate
CAS：6018-19-5
分子式：C7H6NNaO3.2H2O
分子量：211.15
外观（性状）：白色至灰褐色粉末或结晶
储存条件：RT
纯度：98%
溶解性：易溶于水
单位：瓶
注意事项：
1. 本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品。
2. 为了您的安全和健康，请穿实验服并戴一次性手套操作。
有效期：
室温保存四年。
| 货号 | BS220-25g |
| 规格 | 25g |
| 品牌 | Jinpan |
| 说明书下载 | 点击下载 |
Sodium Molybdate Dihydrate
| CAS | 10102-40-6 |
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 200mg |
Sodium Tartrate Dihydrate
| CAS | 6106-24-7 |
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 500mg/vial;4vials |
D-海藻糖,D-(+)-Trehalose dihydrate,CAS：6138-23-4,货号：G8570-10g
| 市场价： | ￥150.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 10g |
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产品详情
说明书下载
参考文献
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D-海藻糖,D-(+)-Trehalose dihydrate,CAS：6138-23-4,货号：G8570-100g
| 市场价： | ￥1000.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 100g |
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产品详情
说明书下载
参考文献
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Quinine Hydrochloride Dihydrate
| CAS | 6119-47-7 |
| 单位 | 瓶 |
| 货期 | 4-6周 |
| 规格 | 1g |
D(+)-Trehalose dihydrate；D-海藻糖二水
| EC | EINECS 202-739-6 |
| MDL | MFCD00071594 |
| 别名 | α,α-Trehalosedihydrate |
| 英文名称 | D(+)-Trehalose dihydrate |
| CAS | 6138-23-4 |
| 分子式 | C12H22O11?2H2O |
| 分子量 | 378.33 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | D-(+)-Trehalose dihydrate可用作食品成分和药物赋形剂。[1] |
| In Vitro | 海藻糖二水合物是一种安全的，天然存在的二糖，用作食品成分和药物赋形剂[1]。 |
| SMILES | O[C@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O.[2 H2O] |
| 靶点 | Others |
| 数据来源文献 | [1]. Megarry AJ, et al. Amorphous trehalose dihydrate by cryogenic milling. Carbohydr Res. 2011 Jun 1;346(8):1061-4. |
| 规格 | 20mg 10mM*1mL in Water 100mg |
D-(+)-Trehalose dihydrate可作赋形剂。
Alvimopan dihydrate/ADL 8-2698 dihydrate；爱维莫潘二水合物
| MDL | MFCD26142939 |
| 别名 | ADL8-2698dihydrate;LY246736dihydrate |
| 英文名称 | Alvimopan dihydrate/ADL 8-2698 dihydrate |
| CAS | 170098-38-1 |
| 分子式 | C25H36N2O6 |
| 分子量 | 460.56 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus[1-[3]. |
| IC50 | 1.7 nM (μ-opioid receptor)[1] |
| In Vitro | Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM[1]. |
| In Vivo | Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres produced by morphine in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats[3]. |
| SMILES | OC1=CC=CC([C@@]2(C)[C@@H](C)CN(C[C@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)CC2)=C1.O.O |
| 靶点 | Opioid Receptor |
| 数据来源文献 | [1] Goldina Ikezuagu Erowele. P T. 2008, 33(10): 574, 580-583. [2] DT Beattie. Clinical Medicine: Therapeutics. 2009, 1: 199-213. |
| 规格 | 5mg 10mg 50mg |
是一种有效的、相对非选择性的opioid拮抗剂