三磷酸腺苷二钠,Adenosine-5'-triphosphate disodium salt hydrate,CAS:987-65-5,货号:A8270-1g
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品牌: | solarbio | |
规格: | 1g |
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三磷酸腺苷二钠,Adenosine-5'-triphosphate disodium salt hydrate,CAS:987-65-5,货号:A8270-1g
市场价: | ¥50.0 | |
价格: |
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品牌: | solarbio | |
规格: | 1g |
产品详情
说明书下载
参考文献
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Adenosine 5′-triphosphate disodium saltCAS号: 987-65-5分子式: C10H14N5O13P3.2Na分子量: 551.14描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
Adenosine 5′-triphosphate disodium salt is a P2 purinoceptor agonist. |
纯度 |
>98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
三磷酸腺苷二钠;腺苷-5′-三磷酸二钠盐;ATP disodium salt
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外观 |
White crystalline powder
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可溶性/溶解性 |
water : 100 mg/mL (181.44 mM; Need ultrasonic)
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生物活性 | |
靶点 |
P2X Receptor
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In vitro(体外研究) |
ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils. ATP results in production of reactive oxygen species (ROS), which stimulates the phosphatidylinositol 3-kinase (PI3K) pathway and subsequent Akt and ERK1/2 activation. ATP-dependent ROS production and PI3K activation also stimulate transcription of genes required for an oxidative stress response. ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18. ATP potently stimulates TNF-alpha release, resulting from TNF-alpha mRNA expression in rat cultured brain microglia. ATP-induced TNF-alpha release is Ca(2+)-dependent, and a sustained Ca(2+) influx correlated with the TNF-alpha release in ATP-stimulated microglia. ATP-induced TNF-alpha release is inhibited by PD 098059, an inhibitor of extracellular signal-regulated protein kinase (ERK) kinase 1 (MEK1), which activates ERK, and also by SB 203580, an inhibitor of p38 mitogen-activated protein kinase. ATP rapidly activates both ERK and p38 even in the JPence of extracellular Ca(2+). ATP-induced cytotoxicity is mediated by classical alterations of apoptosis, including membrane blebbing, nuclear condensation, and DNA fragmentation. ATP but not other nucleotides lead to the potent and selective activation of NF-κB in microglial cells through a P2Z receptor-mediated pathway.
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In vivo(体内研究) |
ATP regulates microglial branch dynamics in the intact mice brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury.
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分子结构图
三磷酸腺苷二钠,Adenosine-5'-triphosphate disodium salt hydrate,CAS:987-65-5,货号:A8270-5g
市场价: | ¥150.0 | |
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品牌: | solarbio | |
规格: | 5g |
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三磷酸腺苷二钠,Adenosine-5'-triphosphate disodium salt hydrate,CAS:987-65-5,货号:A8270-25g
市场价: | ¥700.0 | |
价格: |
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品牌: | solarbio | |
规格: | 25g |
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参考文献
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Uridine triphosphate trisodium salt;尿苷-5′-三磷酸三钠
EC | EINECS 243-347-5 |
MDL | MFCD00044310 |
别名 | 尿苷三磷酸三钠 |
英文名称 | Uridine triphosphate trisodium salt |
CAS | 19817-92-6 |
分子式 | C9H12N2O15P3Na3 |
分子量 | 550.09 |
纯度 | HPLC≥98% |
单位 | 瓶 |
SMILES | O[C@@H]([C@H]([C@H](N1C(NC(C=C1)=O)=O)O2)O)[C@H]2COP([O-])(OP([O-])(OP([O-])(O)=O)=O)=O.[Na+].[Na+].[Na+] |
靶点 | DNA/RNA Synthesis |
规格 | 20mg 100mg |
腺苷-5′-三磷酸 标准品
EC | EINECS 200-283-2 |
MDL | MFCD00150755 |
别名 | 三磷腺苷;ATP;Adenosine triphosphate; |
英文名称 | Adenosine Triphosphate |
CAS | 56-65-5 |
分子式 | C10H16N5O13P3 |
分子量 | 507.18 |
储存条件 | -20℃ |
纯度 | HPLC≥98% |
外观(性状) | Off-white Powder |
单位 | 瓶 |
SMILES | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(OP(O)(O)=O)(O)=O)=O |
规格 | 20mg |
Adenosine triphosphate/ATP;腺苷-5′-三磷酸
EC | EINECS 200-283-2 |
MDL | MFCD00150755 |
别名 | 三磷腺苷;ATP |
英文名称 | Adenosine triphosphate/ATP |
CAS | 56-65-5 |
分子式 | C10H16N5O13P3 |
分子量 | 507.18 |
纯度 | HPLC≥98% |
单位 | 瓶 |
In Vitro | ATP(100-300μM)抑制TNF-α的产生32±8%,并且在300μM时,LPS + PHA刺激的全血中TNF-α产生的减少为65±4%。在LPS + PHA刺激的全血中,ATP(100,300μM)分别使IL-10水平增加48±5%(p = 0.01)和62±7%。 ATP不会显著改变IL-6的产生。 |
SMILES | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(OP(O)(O)=O)(O)=O)=O |
靶点 | Endogenous Metabolite |
数据来源文献 | [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5′-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. |
规格 | 20mg 10mM*1mL in Water 100mg |
ATP 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。