标签归档：aldosterone

醛固酮Aldosterone ELISA 试剂盒

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醛固酮Aldosterone ELISA 试剂盒

Aldosterone ELISA kit   ADI-900-173   ADI-901-173

醛固酮检测试剂盒

灵敏度： 4.7 pg/ml

检测范围： 3.9 – 250 pg/ml

样本类型： 血清，血浆，尿液

适用种属：  无种属特异性，适用于任何物种。


货号

产品名称

规格

灵敏度

中文名称

品牌

ADI-900-173

Aldosterone ELISA kit

96 test

4.7 pg/ml

醛固酮检测试剂盒

ENZO(美国)

ADI-901-173

Aldosterone ELISA kit

5×96 wells

4.7 pg/ml

醛固酮检测试剂盒

ENZO(美国)


文献引用：

Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice: C. K. Hathaway, et al.; PNAS (2015), Application(s): ELISA using mouse plasma, Abstract; Full Text

Effect of buttermilk consumption on blood pressure in moderately hypercholesterolemic men and women: V. Conway, et al.; Nutrition 30, 116 (2014), Application(s): ELISA using human plasma, Abstract;

Effect of renal sympathetic denervation on the progression of paroxysmal atrial fibrillation in canines with long-term intermittent atrial pacing: X. Wang, et al.; Europace (2014), Application(s): ELISA using dog plasma, Abstract;

Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats: I. Dhar, et al.; Am. J. Hypertens. 27, 308 (2014), Application(s): ELISA using rat plasma, Abstract;

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure: Y.N. Qiao, et al.; J. Biol. Chem. 289, 22512 (2014), Application(s): ELISA using mouse plasma,Abstract;

Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome: T. Katayama, et al.; J. Am. Heart. Assoc. 2, e000197 (2013), Application(s): ELISA using rat urine, Abstract; Full Text

Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions: J. Mittag, et al.; J. Clin. Invest. 123, 509 (2013), Application(s): ELISA using mouse serum, Abstract; Full Text

Aldosterone induces active K+ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon: S.K. Singh, et al.; Am. J. Physiol. Cell Physiol. 302, C1353 (2012), Application(s): ELISA using rat serum, Abstract; Full Text

ENZO热销产品—— Aldosterone ELISA kit

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ENZO热销产品—— Aldosterone ELISA kit

醛固酮（Aldosterone）是一种由肾上腺皮质中的胆固醇合成的类固醇激素。醛固酮在肾脏和肝脏中代谢，并作为控制钠钾平衡的关键盐皮质激素发挥作用。肾上腺合成和释放醛固酮主要受肾素-血管紧张素-醛固酮系统（RAAS）的调节，RAAS主要作用是调节和维持血压、水电解质平衡和维持人体内环境稳态。检测血清醛固酮和血浆肾素在临床上用于区分原发性和继发性醛固酮增多症。原发性醛固酮增多症（醛固酮增多症）的特征是肾素与醛固酮比率非常低，导致钠滞留和血压升高，通常是肾腺增生或肿瘤的结果。在继发性醛固酮增多症中，醛固酮的过量产生是由心力衰竭和肾动脉疾病等外部条件引起的。


ENZO Aldosterone ELISA kit是一种比色竞争法酶免疫检测试剂盒，过夜 + 1 小时可以得到检测结果。

 

● 高灵敏度，可检测低至4.7 pg/ml的醛固酮

● 几乎不与其他类固醇反应

● 经过人和啮齿动物血清和血浆样本验证和测试

● 超越半定量Western blot分析的全定量检测

 

ENZO热销产品—— Aldosterone ELISA kit

 

产品信息

产品货号

ADI-900-173/ ADI-901-173

产品名称

Aldosterone ELISA kit（醛固酮ELISA试剂盒）

规格

96 wells/ 5×96 wells

灵敏度

4.7 pg/ml

检测范围

3.9 – 250 pg/ml

检测时间

Overnight + 1 hour

样本种属

Species independent

样本类型

plasma, serum, and urine

保存温度

Store all components at -20°C

试剂盒组分

DxS IgG Microtiter plate, Conjugate, Antibody, Assay buffer concentrate, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution

 

部分产品引用文献

1. A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1: J.O. Kang, et al.; PLoS One 17, e0267938 (2022)

2. Effects of amiloride on acetylcholine-dependent arterial vasodilation evolve over time in mice on a high salt diet: S.M. Mutchler, et al.; Physiol. Rep. 10, e15255 (2022)

3. Low-salt diet increases mRNA expression of aldosterone-regulated transporters in the intermediate portion of the endolymphatic sac: A. Matsubara, et al.; Pflugers Arch. (2022)

4. The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal: Z. Nouri, et al.; NPJ Biofilms Microbiomes 8, 16 (2022)

5. The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection: L.M. Amezcua-Guerra, et al.; Ther. Adv. Respir. Dis. 16, 17534666221122544 (2022)

6. Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise: K. Hasegawa, et al.; Physiol. Rep. 9, e14670 (2021), Application(s): ELISA using rat plasma

7. Factors affecting the urinary aldosterone-to-creatinine ratio in healthy dogs and dogs with naturally occurring myxomatous mitral valve disease: A. Galizzi, et al.; BMC Vet. Res. 17, 15 (2021), Application(s): ELISA using dog urine

8. Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury: N. Ramkumar, et al.; Circ. Res. 129, 50 (2021), Application(s): Mouse urine and plasma

9. Metabolic syndrome during gestation and lactation: An important renal problem in dams. selenium renal clearance: F. Nogales, et al.; J. Trace Elem. Med. Biol. 64, 126709 (2021), Application(s): ELISA using rat serum

10. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions: K. Miyauchi, et al.; EBioMedicine 64, 103209 (2021), Application(s): ELISA using rat plasma

11. Salt-Sensitivity of Volume and Blood Pressure in a Mouse with Globally Reduced ENaC γ Subunit Expression: E.C. Ray, et al.; Am. J. Physiol. Renal Physiol. 321, F705 (2021)

12. Sex-dependent Effects of Nephron Ift88 Disruption on Blood Pressure, Renal Function and Cystogenesis: C. Hu, et al.; J. Am. Soc. Nephrol. 32, 2210 (2021)

13. The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males: T. Tominaga, et al.; Antioxidants (Basel) 10, 866 (2021), Application(s): Aldosterone quantification on human plasma samples

14. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)

15. Differences in Renal BMAL1 Contribution to Na + Homeostasis and Blood Pressure Control in Male and Female Mice: G.R. Crislip, et al.; Am. J. Physiol. Renal Physiol. 318, 1463 (2020)

16. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion: A. Berthon, et al.; Hum. Mol. Genet. 2020, ddaa215 (2020)

更多详情请咨询Enzo Life Sciences全国代理商-上海金畔生物

Aldosterone 醛固酮

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Aldosterone 醛固酮

货号：
IA0700

品牌：
Jinpan

Aldosterone 醛固酮

暂无详情
产品简介
MDL MFCD00051136
EC EINECS 200-139-9
别名 醛甾酮;Aldocortin
英文名称 Aldosterone
CAS 52-39-1
分子式 C21H28O5
分子量 360.44
纯度 HPLC≥97%
生物活性 Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。[1-5]
In Vitro 醛固酮（1-1000nm；24小时）以剂量依赖的方式抑制白细胞介素-1β刺激的血管平滑肌细胞产生亚硝酸盐[3]。
In Vivo 醛固酮（1 mg/Kg+1%NaCl；i.h.；每日1次，持续3周）显著升高收缩压（SBP）、舒张压（DBP）、左室收缩压（LVSP）和左室舒张末压（LVEDP）[4]。醛固酮（0.72 mg/kg/天；14天）使雄性小鼠血压略微升高（14 mmHg）[5]。动物模型：40只雄性Wistar大鼠[4]剂量：1 mg/Kg（+1%NaCl）给药：i.h；每日1次，连续3周。结果：醛固酮盐组大鼠收缩压（SBP）、舒张压（DBP）、左室收缩压（LVSP）和左室舒张末压（LVEDP）明显升高。
SMILES O=C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
靶点 Sodium Channel
数据来源文献 [1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223.

[2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.

[3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73.

[4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104.

[5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
规格 1mg/支

是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。