产品货号: C5080
产品规格: 5 mg
目录价（元）:1700
大包装询价
产品概述：
储存条件
-20℃避光保存，有效期见外包装。
产品介绍
花菁染料Cy dye free acid系列是一类荧光标记染料，含有游离的、未活化的单官能团羧酸，其中Cy free acid是非水溶性形式，Sulfo-Cy free acid是磺酸化的高水溶性形式。在多数情况下，该系列染料不具有反应活性，可用于样品对照或仪器校准。
注意事项
1. 使用前请将产品瞬时离心至管底，再进行后续实验。
2. 荧光染料均存在淬灭问题，请尽量注意避光，以减缓荧光淬灭。
3. 为了您的安全和健康，请穿实验服并戴一次性手套操作。
说明书：
UE-C5080
MSDS：
MSDS Cy dye free acid
Dorsomorphin free baseCAS号： 866405-64-3分子式： C24H25N5O分子量： 399.49描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
BML-275; Compound C; BML275; BML 275
|
| 外观 |
white to beige Powder
|
| 可溶性/溶解性 |
DMSO : 3 mg/mL (7.5 mM), warmed
Ethanol : 2 mg/mL (5.0 mM), warmed |
| 生物活性 | |
| 靶点 |
AMPK
|
| In vitro(体外研究) |
Dorsomorphin inhibits ACC inactivation by either AICAR or metformin, and also attenuates AICAR and metformin’s effect to increase fatty acid oxidation or suppress lipogenic genes in hepatocytes. Inhibition of AMPK activity by Dorsomorphin almost completely inhibits autophagic proteolysis in HT-29 cells. in addition, Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6, and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.
|
| In vivo(体内研究) |
Dorsomorphin (10 mg/kg) reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice. Dorsomorphin (0.2 mg/kg, i.v.) significantly reduces VCAM-1 and ICAM-1 expression in the thoracic aorta of LPS-treated rats.
|
分子结构图
GeneJET Endo-Free Plasmid Maxiprep Kit
| 单位 | 支 |
| 规格 | 10 rxns |
产品货号: S9050S/S9050L
产品规格: 50mL/100mL
目录价（元）:198/338
大包装询价
产品概述：
储存条件
-20℃保存，有效期见外包装。
产品介绍
注意事项
说明书：
UE-S9050S/S9050L
PD0332991(free base)CAS号： 571190-30-2分子式： C24H29N7O2分子量： 447.53描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
PD0332991; PD-0332991; PD 0332991
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
Water：30 mg/mL (61.98 mM)
DMSO：3 mg/mL warmed (6.19 mM) |
| 生物活性 | |
| 靶点 |
CDK
|
| In vitro(体外研究) |
The IC50 of Palbociclib (PD 0332991) for reduction of retinoblastoma (Rb) phosphorylation at Ser780 in MDA-MB-435 breast carcinoma cells is 66 nM. Palbociclib is equally effective at reducing Rb phosphorylation at Ser795 in this tumor with an IC50 of 63 nM, and similar effects on both Ser780 and Ser795 phosphorylation are obtained in the Colo-205 colon carcinoma. The MP-MRT-AN (AN), KP-MRT-RY (RY), G401, and KP-MRT-NS (NS) cell lines are effectively inhibited by Palbociclib (PD) in a concentration-dependent manner in a WST-8 assay. The IC50s are 0.01 µM, 0.01 µM, 0.06 µM, and 0.6 µM, respectively. In contrast, the KP-MRT-YM (YM) cell line is resistant to Palbociclib (IC50>10 µM). The flow cytometry results show that Palbociclib at concentrations between 0 to 1.0 µM induces G1 arrest in the AN, RY, G401 and NS cell lines in a concentration-dependent manner, but has no effect on YM cells. The BrdU incorporation results are consistent with the WST-8 and flow cytometry results: PD reduces BrdU incorporation (indicating G1 arrest) in the AN, RY, G401 and NS cell lines, but not in the YM cell line. Palbociclib, even at a concentration of 0.05 µM, significantly reduces BrdU incorporation in the AN, RY, and G401 cell lines (p.
|
| In vivo(体内研究) |
Palbociclib (PD 0332991) exhibits significant antitumor efficacy against multiple human tumor xenograft models. In mice bearing Colo-205 colon carcinoma xenografts (p16 deleted), daily p.o. dosing for 14 days with Palbociclib (150 or 75 mg/kg) produces rapid tumor regressions and a corresponding tumor growth delay of ~50 days with >1 log of tumor cell kill at the highest dose tested. At 37.5 mg/kg, the tumor slowly regressed during treatment. Even at doses as low as 12.5 mg/kg, a 13-day growth delay is obtained indicating a 90% inhibition of tumor growth rate. Likewise, robust antitumor activity is seen in the MDA-MB-435 breast carcinoma (p16 deleted) where complete tumor stasis is apparent at 150 mg/kg and some cell kill is evident at the highest dose.
|
| 参考文献 | |
| 参考文献 |
[1] Fry DW, et al. Mol Cancer Ther, 2004, 3(11), 1427-1438.
[2] Menu E, et al. Cancer Res, 2008, 68(14), 5519-5523. [3] Finn RS, et al. Breast Cancer Res, 2009, 11(5), R77. |
分子结构图
Water, nuclease-free
| 单位 | 支 |
| 规格 | 4×1.25ml |
IPTG, DIOXANE-FREE
| 单位 | 支 |
| 规格 | 5x5g |
IPTG, DIOXANE-FREE
| 单位 | 支 |
| 规格 | 5g |
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Storage Temperature
产品货号: YH0090
产品规格: 5mg
目录价（元）:3200
大包装询价
产品概述：
YO Dye Free acid（羧酸）
|
货号 |
名称 |
规格 |
外观颜色 |
Absmax/Em (nm) |
Extinction coefficient(ε) |
MW |
|
YH0097 |
YO390 free acid（羧酸） |
5 mg |
黄色 |
390/464 |
24,000 |
357.5 |
|
YH0090 |
YO550 free acid（羧酸） |
5 mg |
红色 |
554/575 |
120,000 |
593.8 |
|
YH0091 |
YO565(6) free acid（羧酸） |
5 mg |
红色 |
553/575 |
120,000 |
611.8 |
|
YH0095 |
YO565(5) free acid（羧酸） |
5 mg |
红色 |
554/578 |
120,000 |
611.8 |
|
YH0092 |
YO700 free acid（羧酸） |
1 mg |
深蓝 |
688/717 |
120,000 |
746.9 |
|
名称 |
光谱图 |
效能等同于 |
|
YO390 free acid（羧酸） |
溶解于甲醇所测 |
ATTO 390 |
|
YO550 free acid（羧酸） |
溶解于水所测 |
ATTO 550 |
|
YO565(6) free acid（羧酸） |
溶解于甲醇所测 |
ATTO 565 |
|
YO565(5) free acid（羧酸） |
溶解于甲醇所测 |
ATTO 565 |
|
YO700 free acid（羧酸） |
溶解于水所测 |
ATTO 700 |
储存条件
-20℃干燥避光保存，有效期见外包装。
产品介绍
说明书：
UE-YH0090
MSDS：
MSDS YO Dye Free acid
