BI 224436CAS号： 1155419-89-8分子式： C27H26N2O4分子量： 442.51描述纯度储存/保存方法注意事项可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
产品描述
描述
BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
纯度
98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
注意事项
该产品在溶液状态不稳定，建议您现用现配，即刻使用。
基本信息
可溶性/溶解性
DMSO : ≥ 50 mg/mL (112.99 mM)
生物活性
靶点
HIV Integrase
In vitro(体外研究)
BI 224436 has cellular cytotoxicity of more than 90 μM. BI 224436 has a low, 2.1-fold decrease in antiviral potency in the presence of 50% human serum. BI 224436 retains full antiviral activity against recombinant viruses encoding INSTI resistance substitutions N155S, Q148H, and E92Q. BI 224436 displays an additive effect in combination with most approved antiretrovirals, including INSTIs. BI 224436 has drug-like in vitro JPorption, distribution, metabolism, and excretion (ADME) properties, including Caco-2 cell permeability, solubility, and low cytochrome P450 inhibition.
In vivo(体内研究)
BI 224436 exhibits excellent pharmacokinetic profiles in rat (clearance as a percentage of hepatic flow , 0.7%; bioavailability , 54%), monkey (CL, 23%; F, 82%), and dog (CL, 8%; F, 81%).
1. Ren, Z. et al. Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy. Circulation, 141, 1704–1719 (2020) 2. Wang, L. et al. Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat. Cell Biol. 22, 108–119 (2020) 3. Krieger, T. G., et al. Modeling Glioblastoma Invasion Using Human Brain Organoids and Single-Cell Transcriptomics. Neuro-Oncology, 22, 1138–1149 (2020) 4. Yekelchyk, M., Guenther, S., Preussner, J. & Braun, T. Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population. Basic Res. Cardiol. 114, 36 (2019)
LONZA 12-725F UltraCULTURE无血清培养基搭配PALL Ultroser G serum substitute血清替代物15950-017培养人间充质干细胞MSC，是非常多科研以及临床用户的选择。
产品
货号
规格
储存
LONZA UltraCULTURE™无血清培养基
12-725F
500mL/瓶
2～8℃
PALL Ultroser G serum substitute血清替代物
15950-017
20mL/瓶
2～8℃
189 2296 8205Q
-客服中心：
提供产品：致力于为中国干细胞领域的干细胞科学研究、脐带血/造血干细胞/脐带/脂肪/胎盘干细胞库、干细胞临床转化医学、干细胞美容及干细胞抗衰老、免疫细胞治疗、T细胞治疗、临床干细胞治疗等再生医学和个体化治疗产业链的相关客户提供：MSC间充质干细胞培养基、iPS/ES胚胎干细胞培养基、血清替代物、羊水培养基、基底膜基质胶细胞支架、干细胞生长分化调控因子、BioMarker 流式检测抗体、支原体检测试剂盒、内毒素检测试剂盒、干细胞存储细胞冻存袋、细胞培养瓶、USP级DMSO二甲基亚砜细胞冻存液、细胞培养相关试剂耗材仪器等种类丰富的产品，以“Focus on improving the quality of Stem Cells专注干细胞研究，提升干细胞品质”为己任，我们与客户携手为中国干细胞产业的发展而前行。
