BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2
BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2
产品描述：
DC101-CP132单克隆抗体是原始DC101单克隆的重组嵌合型抗体。可变结构域序列与原始DC101相同，但是恒定区序列已经从大鼠IgG1变为小鼠IgG2a。DC101-CP132单克隆抗体像原始大鼠IgG1抗体一样，不包含Fc突变。
DC101-CP132单克隆抗体能与小鼠VEGFR-2(血管内皮生长因子受体2)反应，VEGFR-2也称为CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成员。当结合到其配体血管内皮生长因子时发挥生理作用，血管内皮生长因子受体-2在血管发育和通透性中起关键作用。血管内皮生长因子受体-2在成人心脏、肺、肾、脑和骨骼肌的内皮细胞中高表达，在其他组织中低表达。DC101单克隆抗体已被证明在体内抑制VEGFR-2信号传导。
产品详情：
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产品名称
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RecombiMAb anti-mouse VEGFR-2
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产品货号
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CP132
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产品规格
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1/5/25/50/100mg
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反应种属
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Mouse
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克隆号
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DC101-CP132
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同种型
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Mouse IgG2a(switched from rat IgG1)
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免疫原
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Mouse VEGFR-2-SEAPs soluble receptor
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实验应用
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in vivo blocking of VEGF/VEGFR-2 signaling*
in vitro blocking of VEGFR signaling*
Western blot*
*Reported for the original rat IgG1 DC101 antibody
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产品形式
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PBS, pH 7.0,Contains no stabilizers or preservatives
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纯度
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>95%, Determined by SDS-PAGE
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聚合
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<5%, Determined by SEC
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无菌处理
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0.2 µm filtration
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纯化方式
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Protein G
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分子量
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150 kDa
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小鼠病原检测
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Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
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保存条件
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抗体原液保存在4°C，不能冷冻保存。
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推荐同型对照
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InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
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推荐抗体稀释液
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InVivoPure pH 7.0 Dilution Buffer（货号IP0070）
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该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：
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应用
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文章
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体内VEGF/VEGFR-2信号阻断
(in vivo blocking of VEGF/VEGFR-2 signaling)
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1. Ding, X., et al. (2015). ‘Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8’ Cancer Res 75(2): 330-343.
2. Lee, H. J., et al. (2015). ‘Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature’ Int J Radiat Oncol Biol Phys 91(3): 621-630.
3. Arulanandam, R., et al. (2015). ‘VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection’ Cancer Cell 28(2): 210-224.
4. Kizhatil, K., et al. (2014). ‘Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process’ PLoS Biol 12(7): e1001912.
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体内VEGF/VEGFR-2信号阻断，体外VEGFR信号阻断
(in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling)
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1.Larrayoz, M., et al. (2014). ‘Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype’ EMBO Mol Med 6(4): 539-550.
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更多产品详情请咨询 BioXCell 中国代理——上海金畔生物
