Solid Tissue Cryopreservation Bags indicated for use in protecting, storing and freezing cells and tissues.
Solid Tissue Cryopreservation Bags indicated for use in protecting, storing and freezing cells and tissues.
Composed of Kapton and FEP, the CryoBag™ can be used at any temperature, including direct immersion in Liquid Nitrogen. It is unexcelled for cryogenic freezing of cells and tissues. The OriGen CryoBag is simply the easiest, safest way to preserve valuable tissue and cell cultures when cryopreservation is indicated.
Designed for cryogenic preservation including direct immersion in liquid nitrogen. The CryoBag remains flexible with no significant decrease in mechanical strength at temperatures from -196°C to +200°C.
Advantages of the OriGen CryoBag
Tape Seal: Where immersion in only the Nitrogen vapor phase is required, a self-adhesive tape seal is available (product code: CT). When storing in the Liquid Nitrogen, a standard heat seal is recommended.
Labels: Supplied with a self-adhesive lot label that will remain attached in liquid nitrogen, or can be placed in a logbook. The freezing bag itself is also silkscreened with a writing area.
Volume: Square seals means that the CryoBag has a much larger internal volume than chevron-seal type cryopreservation freezing bags.
Materials: The Cryobag is made from a sandwich of polyimide Kapton and FEP films. The inner surface of the CryoBag bag is pure FEP, which has unsurpassed biocompatibility. The outer layer is polyimide which is gas impermeable, making the bag recommended for direct immersion in liquid nitrogen.
Inert: The inner layer of FEP contains no plasticizers or chemical residuals, so there is nothing to leech out into the stored cells.
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
纯度
>98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名
比瑞那帕；TL-32711；TL 32711
外观
类白色至淡黄色固体
可溶性/溶解性
DMSO : 93 mg/mL (115.3 mM)
Ethanol : 51 mg/mL (63.2 mM)
生物活性
靶点
cIAP1 ,XIAP
In vitro(体外研究)
Birinapant binds with XIAP and cIAP1 with Kd of 45 and Birinapant in combination with TNF-α exhibits a strong antimelanoma effect in vitro. Birinapant in combination with TNF-α(1 ng/mL) inhibits the growth of human melanoma cell lines WTH202, WM793B, WM1366 and WM164 with IC50s of 1.8, 2.5, 7.9 and 9 nM, respectively, while neither compound is effective individually. Birinapant singly treatment induces inhibition on proliferation of WM9 cells with IC50 of 2.4 nM. Birinapant significantly inhibits the target protein cIAP1 and cIAP2 in these cell lines.
In vivo(体内研究)
Birinapant (30 mg/kg) treatment significantly induces abrogation of tumor growth in melanoma xenotransplantation models 451Lu with.
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