CD2665CAS号： 170355-78-9分子式： C31H34O5分子量： 486.6描述纯度储存/保存方法参考文献
| 产品描述 | |
| 描述 |
CD2665 is a selective retinoic acid receptor (RAR)β and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).1 At 10-7 M, it has been used to abrogate retinoic acid (Item No. 11017)-induced antiproliferative and antidifferentiative effects on sebocyte growth.1 This compound has been used in animal and in vitro cell models to explore the role of retinoid signaling in a number of biological processes including memory formation and tumor proliferation.2,3
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20℃
|
| 参考文献 | |
| 参考文献 |
1.Kim, M.J.,Ciletti, N.,Michel, S., et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. Journal of Investigative Dermatology 114, 349-353 (2000).
2.Alfos, S.,Boucheron, C.,Pallet, V., et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcholism: Clinical and Experimental Research 25(10), 1506-1514 (2001). 3.Marikar, Y.,Wang, Z.Q.,Duell, E.A., et al. Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells. Journal of Investigative Dermatology 111(3), 434-439 (1998). |
分子结构图
